Mar 27, 2020

Neuropsychological and psychiatric outcomes in encephalitis: A multi-centre case-control study

PloS One
Lara HarrisENCEPH UK study group

Abstract

Our aim was to compare neuropsychological and psychiatric outcomes across three encephalitis aetiological groups: Herpes simplex virus (HSV), other infections or autoimmune causes (Other), and encephalitis of unknown cause (Unknown). Patients recruited from NHS hospitals underwent neuropsychological and psychiatric assessment in the short-term (4 months post-discharge), medium-term (9-12 months after the first assessment), and long-term (>1-year). Healthy control subjects were recruited from the general population and completed the same assessments. Patients with HSV were most severely impaired on anterograde and retrograde memory tasks. In the short-term, they also showed executive, IQ, and naming deficits, which resolved in the long-term. Patients with Other or Unknown causes of encephalitis showed moderate memory impairments, but no significant impairment on executive tests. Memory impairment was associated with hippocampal/medial temporal damage on magnetic resonance imaging (MRI), and naming impairment with left temporal and left frontal abnormalities. Patients reported more subjective cognitive complaints than healthy controls, with tiredness a significant problem, and there were high rates of depression and anxiety in th...Continue Reading

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Mentioned in this Paper

Problem
Encephalitis
Mental Depression
Anxiety
Case-Control Studies
Left Frontal Vein
Autoimmune Diseases
Retrograde Direction
Naming, Function
Human herpes simplex virus

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