Neuropsychological and psychiatric sequelae of pallidotomy for PD: clinical trial findings

Neurology
J GreenM R DeLong

Abstract

To evaluate the neuropsychological and psychiatric sequelae of unilateral posterior pallidotomy for treatment of PD. Patients with idiopathic PD completed baseline and 3- and 6-month assessments after random assignment to an immediate surgery (n = 17) or medical management (n = 16) group. Compared with the medical management group, the immediate surgery group with single lesions centered on the posterior internal pallidum showed superior naming and response inhibition, better verbal recall at 6 months, but greater distractibility, a tendency toward lower phonemic fluency, and a transient (3 months' only) semantic fluency deficit. The group with left lesions had more neuropsychological deficits than the group with right lesions or the medical management group, although these occurred mainly at 3 (but not 6) months. At 6 months, the patients with left lesions showed better verbal memory retention than the patients with right lesions. On most measures, the pattern of individual clinical change did not differ as a function of surgery or lesion laterality, with the exception of a higher frequency of decline in phonemic fluency in the patients with left lesions at 6 months. Although psychiatric status did not change overall, a histor...Continue Reading

Citations

Apr 11, 2003·Current Psychiatry Reports·Laura Marsh, Ariel Berk
Jun 6, 2003·Applied Neuropsychology·Alexander I TrösterJulie A Fields
Jun 4, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michel Desmurget, Robert S Turner
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Sep 25, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Brooke-Mai WhelanBruce Hall
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May 6, 2003·Annals of Neurology·Jerrold L VitekMahlon R DeLong
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Nov 24, 2004·Lancet Neurology·Benjamin L Walter, Jerrold L Vitek
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