Neuropsychological approaches for the detection and evaluation of toxic symptoms

Environmental Health Perspectives
N Fiedler

Abstract

The purpose of this paper is 3-fold: a) to review briefly the neuropsychological tests that have been used to evaluate the effects of neurotoxicants; b) to identify individual factors that may create heightened sensitivity to neurotoxicants; and c) to discuss test parameters that will increase the sensitivity of neuropsychological tests for detecting symptoms in low-level exposure situations. While the body of literature on neurobehavioral toxicology has increased dramatically during the past 10 years, it remains difficult to discern which tests are most effective in detecting behavioral effects even among workers with significant exposures. Few investigators have evaluated the interactions between individual differences, such as gender and psychiatric function, and exposure to neurotoxicants. Detection of behavioral performance decrements among uniquely susceptible populations such as those with sensitivities to low-level exposures (e.g., multiple chemical sensitivities) will require more difficult tests than are frequently used in current neuropsychological test batteries.

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Citations

Jan 1, 2000·Occupational and Environmental Medicine·R AkilaV Riihimäki
Jun 24, 2003·Occupational and Environmental Medicine·W Kent Anger
Apr 1, 1996·Environmental Health Perspectives·N FiedlerA Wetherell
Mar 30, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J H Kolaczinski, C F Curtis
Mar 15, 2003·Risk Analysis : an Official Publication of the Society for Risk Analysis·David C Bellinger
May 17, 2005·International Archives of Occupational and Environmental Health·Roberto LucchiniLorenzo Alessio
Sep 23, 2011·Scandinavian Journal of Occupational Therapy·Jennifer FlemingJanell Griffin
Nov 28, 2006·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Karl E FriedlRobert L Kane

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