PMID: 8459785Jan 1, 1993Paper

Neuropsychological correlates of low-level lead exposure in school-age children: a prospective study

Neurotoxicology and Teratology
K M Stiles, D C Bellinger

Abstract

The neuropsychological underpinnings of lead-associated deficits in general cognitive abilities and academic achievement were investigated in a cohort of 148 middle and upper-middle class 10 year-olds. Scores on a battery of neuropsychological tests were examined in relation to blood lead levels measured at birth and ages 6, 12, 18, 24, 57 months, and 10 years. Although numerous indices of the level, nature, and variability to children's performance on the WISC-R were associated with blood lead level measured at 24 months of age (pb24), relatively few significant associations were noted between specific measures of neuropsychological functions and pb24 (or other blood lead measurements). Some evidence was found for an association between recently measured lead levels and qualitative aspects of a child's performance (e.g. perseveration). The presence of more significant lead effects on broad-based measures of functioning than on neuropsychological tests may be attributable to the use of insensitive measures of neuropsychologic function, limitations in coverage provided by the tests, the nature of lead's CNS impact, or individual differences in biologic vulnerability to lead.

References

Mar 29, 1979·The New England Journal of Medicine·H L NeedlemanP Barrett
May 1, 1990·Neurotoxicology and Teratology·J M DavisL D Grant
Aug 25, 1988·The New England Journal of Medicine·A J McMichaelR J Roberts
Apr 23, 1987·The New England Journal of Medicine·D BellingerM Rabinowitz
Oct 1, 1986·Journal of Clinical and Experimental Neuropsychology·D P Waber, J M Holmes
Jun 1, 1985·Journal of Clinical and Experimental Neuropsychology·D P Waber, J M Holmes
Aug 1, 1985·Journal of Consulting and Clinical Psychology·R L Ownby, C G Matthews
Jan 1, 1985·International Archives of Occupational and Environmental Health·J HunterR Lansdown
Aug 1, 1967·Journal of Psychosomatic Research·T H Holmes, R H Rahe

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Citations

Jul 14, 1999·Journal of Biochemical and Molecular Toxicology·P SunG E Isom
Jul 2, 2003·Neurotoxicity Research·Carla Marchetti
Apr 15, 1996·Environmental Toxicology and Pharmacology·H W TangY X Liang
Apr 29, 2004·Neurotoxicology and Teratology·Lisa M ChiodoJoseph L Jacobson
Jul 19, 2000·Pharmacology, Biochemistry, and Behavior·V Gupta, K D Gill
Jun 19, 1998·Pharmacology, Biochemistry, and Behavior·B J Brockel, D A Cory-Slechta
Jul 27, 1999·Pharmacology, Biochemistry, and Behavior·B J Brockel, D A Cory-Slechta
Feb 21, 2003·Social Science & Medicine·Florence Margai, Norah Henry
May 1, 1996·Neurotoxicology and Teratology·D C Rice
Nov 27, 1998·Neurotoxicology and Teratology·S A FergusonP H Siitonen
Feb 19, 1999·Neurotoxicology and Teratology·S J RothenbergC Hernández
Mar 12, 2004·Journal of the International Neuropsychological Society : JINS·M Douglas RisRobert L Bornschein
Mar 1, 1993·Archives of Environmental Health·K N Dietrich
May 13, 2008·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Donald T WigleDaniel Krewski
May 4, 2010·Annual Review of Nutrition·Katarzyna Kordas
Nov 11, 2011·International Journal of Occupational and Environmental Health·Veronica IglesiasPaulina Pino
Jul 28, 2004·Developmental Neuropsychology·Richard L CanfieldDeborah A Cory-Slechta
Sep 11, 2010·Environmental Health Perspectives·Paul A EubigSusan L Schantz
Sep 1, 1995·Environmental Health Perspectives·K R Mahaffey
Dec 1, 1995·Environmental Health Perspectives·D C Rice
Apr 1, 1996·Environmental Health Perspectives·D C RiceC Watanabe
Dec 31, 1997·Environmental Health Perspectives·G A WassermanJ H Graziano
Apr 30, 2005·Archives of Environmental Health·Carla CampbellDouglas W Dockery
Sep 30, 2005·Archives of Environmental Health·Paulina PinoBetsy Lozoff
Dec 19, 2009·Environmental Health Perspectives·Ananya RoyKalpana Balakrishnan
Jun 6, 2009·Pediatrics International : Official Journal of the Japan Pediatric Society·Hoda Yahya TomoumSamah Mohammed Ahmed
Sep 20, 2005·Environmental Research·Katarzyna KordasRebecca J Stoltzfus
Jan 31, 2006·Environmental Research·T I Lidsky, J S Schneider
Jun 27, 2008·Environmental Health : a Global Access Science Source·R SmoldersG Schoeters
Mar 1, 2012·Neurotoxicology·Evelyn Tiffany-Castiglioni, Yongchang Qian
Dec 13, 2002·Brain : a Journal of Neurology·Theodore I Lidsky, Jay S Schneider
Oct 18, 2000·The Journal of Pediatrics·G A WassermanJ H Graziano
Aug 10, 2010·The Science of the Total Environment·Vania B RezendeJose E Tanus-Santos
Apr 29, 2006·Neurotoxicology·Jin-Young MinDomyung Paek
Jun 24, 2010·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Vania B RezendeJose E Tanus-Santos

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