Abstract
Bone marrow transplantation (BMT) involves conditioning with cyclophosphamide and, for patients with malignant disease, total body irradiation (TBI). This study describes the neuropsychological development of 10 children treated for leukemia (n = 7), neuroblastoma (n = 1) or severe aplastic anemia (SAA; n = 2) at 3 years of age or younger. A moderate general developmental delay, with pronounced motor deficits and varying degrees of perceptual and cognitive problems, was observed in all children treated for malignant disease. Children treated for SAA had normal development. We conclude that BMT, including TBI, can be directly associated with long-term neuropsychological impairment in children treated at a very young age. Continued medical and psychological follow-up procedures are needed.
References
Apr 13, 1978·The New England Journal of Medicine·N Peylan-RamuG Di Chiro
May 1, 1978·Archives of Disease in Childhood·C Eiser
Feb 1, 1976·Cancer·A T Meadows, A E Evans
Feb 1, 1977·Journal of Consulting and Clinical Psychology·D T Stuss, R L Trites
Feb 1, 1976·Cancer·S McIntoshH A Pearson
Jan 1, 1976·International Journal of Radiation Oncology, Biology, Physics·M S VerzosaD P Pinkel
Feb 1, 1975·Cancer·R A Price, P A Jamieson
Jan 1, 1991·Bone·R B Martin, S L Zissimos
May 1, 1990·Anaesthesia·T Jordan, D M Griffiths
Aug 1, 1990·Journal of the Royal Society of Health·R Griffiths
Jun 1, 1990·Acta paediatrica Scandinavica·A C SmedlerP Bolme
Aug 1, 1988·Journal of Clinical and Experimental Neuropsychology·J M Fletcher, D R Copeland
Jan 1, 1988·Hormone Research·B Borgström, P Bolme
May 1, 1985·The Journal of Pediatrics·P BrouwersD G Poplack
Jun 1, 1972·Archives of Disease in Childhood·H E KayE N Thompson
Nov 7, 1981·Lancet·A T MeadowsK Moss
May 1, 1982·Transplantation·O RingdénB Gullbring
Aug 1, 1982·Perceptual and Motor Skills·B B Armstrong, K F Knopf
Oct 1, 1981·Journal of Clinical Neuropsychology·M SeidenbergT J Boll
Mar 1, 1995·Acta Paediatrica·A C SmedlerP Bolme
Citations
Jul 9, 2002·British Journal of Haematology·Alison D Leiper
Nov 16, 2004·International Journal of Hematology·Yozo NakazawaKenichi Koike
Jun 13, 2002·Acta Ophthalmologica Scandinavica·Ulla EkErik Kock
Mar 1, 1997·Journal of Pediatric Hematology/oncology·M A McCabeR Quinones
Dec 8, 2015·Bone Marrow Transplantation·M C CupitS K Hashmi
May 31, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Jessica WardWilliam T Tse
May 3, 2007·Pediatric Blood & Cancer·Joanna L PerkinsK Scott Baker
Aug 1, 2012·Pediatric Blood & Cancer·Jean M Mulcahy LevyArthur K Liu
May 7, 2002·Applied Neuropsychology·S WinqvistM Lanning
Dec 14, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Susan K ParsonsKirsten K Ness
Mar 1, 1995·Acta Paediatrica·A C SmedlerP Bolme
Sep 29, 2001·Journal of Child Neurology·V Kieffer-RenauxC Kalifa
Apr 19, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sean PhippsMaggi Dunavant
Jan 26, 1999·Medical and Pediatric Oncology·L PirichM Kletzel
Aug 6, 2008·Bone Marrow Transplantation·A-C Smedler, J Winiarski
Jul 24, 2018·CNS Spectrums·Gabriella PravettoniAlberto Priori
Jan 19, 2018·Bone Marrow Transplantation·David BuchbinderBronwen E Shaw
Apr 15, 2003·Bone Marrow Transplantation·P NotteghemO Hartmann
Apr 12, 2005·Bone Marrow Transplantation·S C Carpentieri, L R Diller
Jul 23, 2008·Blood·Penny TitmanH Bobby Gaspar
Nov 24, 2005·Hematology·Smita Bhatia
Mar 1, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S PhippsR K Mulhern
Feb 9, 2018·Pediatric Transplantation·Kristina Teär FahnehjelmUlla Ek
Sep 18, 2020·Radiation Research·Rachel N AndrewsJ Mark Cline