PMID: 7540899Apr 1, 1995Paper

Neuropsychological deficits in very young bone marrow transplant recipients

Acta Paediatrica
A C Smedler, P Bolme

Abstract

Bone marrow transplantation (BMT) involves conditioning with cyclophosphamide and, for patients with malignant disease, total body irradiation (TBI). This study describes the neuropsychological development of 10 children treated for leukemia (n = 7), neuroblastoma (n = 1) or severe aplastic anemia (SAA; n = 2) at 3 years of age or younger. A moderate general developmental delay, with pronounced motor deficits and varying degrees of perceptual and cognitive problems, was observed in all children treated for malignant disease. Children treated for SAA had normal development. We conclude that BMT, including TBI, can be directly associated with long-term neuropsychological impairment in children treated at a very young age. Continued medical and psychological follow-up procedures are needed.

References

Feb 1, 1977·Journal of Consulting and Clinical Psychology·D T Stuss, R L Trites
Feb 1, 1976·Cancer·S McIntoshH A Pearson
Jan 1, 1976·International Journal of Radiation Oncology, Biology, Physics·M S VerzosaD P Pinkel
May 1, 1990·Anaesthesia·T Jordan, D M Griffiths
Aug 1, 1990·Journal of the Royal Society of Health·R Griffiths
Aug 1, 1988·Journal of Clinical and Experimental Neuropsychology·J M Fletcher, D R Copeland
Jan 1, 1988·Hormone Research·B Borgström, P Bolme
Jun 1, 1972·Archives of Disease in Childhood·H E KayE N Thompson
Aug 1, 1982·Perceptual and Motor Skills·B B Armstrong, K F Knopf
Oct 1, 1981·Journal of Clinical Neuropsychology·M SeidenbergT J Boll

❮ Previous
Next ❯

Citations

Jul 9, 2002·British Journal of Haematology·Alison D Leiper
Mar 1, 1997·Journal of Pediatric Hematology/oncology·M A McCabeR Quinones
May 31, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Jessica WardWilliam T Tse
May 7, 2002·Applied Neuropsychology·S WinqvistM Lanning
Dec 14, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Susan K ParsonsKirsten K Ness
Sep 29, 2001·Journal of Child Neurology·V Kieffer-RenauxC Kalifa
Apr 19, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sean PhippsMaggi Dunavant
Jul 24, 2018·CNS Spectrums·Gabriella PravettoniAlberto Priori
Apr 12, 2005·Bone Marrow Transplantation·S C Carpentieri, L R Diller
Nov 24, 2005·Hematology·Smita Bhatia
Mar 1, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S PhippsR K Mulhern

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.