May 23, 2008

Neuropsychological function and dysfunction in schizophrenia and psychotic affective disorders

Schizophrenia Bulletin
Abraham ReichenbergEvelyn Bromet


Mounting evidence suggests that compromised neurocognitive function is a central feature of schizophrenia. There are, however, schizophrenia patients with a normal neuropsychological (NP) performance, but estimates of the proportion of NP normal patients vary considerably between studies. Neurocognitive dysfunction is also a characteristic of other psychotic disorders, yet there are inconsistencies in the literature regarding the similarity to impairments in schizophrenia. NP normality in psychotic affective disorders has not been systematically studied. Data came from the Suffolk County Mental Health Project, an epidemiological study of first-admission patients with psychotic disorders. Respondents with a diagnosis of schizophrenia (N = 94) or schizoaffective disorder (N = 15), bipolar disorder (N = 78), and major depressive disorder (N = 48) were administered a battery of NP tests assessing 8 cognitive domains 2 years after index admission. Patients' performance profile was compared, and their NP status was classified based on 3 previously published criteria that vary in their stringency. The 4 diagnostic groups had comparable NP performance profile patterns. All groups demonstrated impairments in memory, executive functions,...Continue Reading

Mentioned in this Paper

Prevalence Studies
Involutional Paraphrenia
Memory for Designs Test
Nasal Provocation Tests
Depressive Disorder
Incidence Studies
Bipolar Disorder
Manic Disorder

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