Neuropsychological functioning of opiate-dependent patients: a nonrandomized comparison of patients preferring either buprenorphine or methadone maintenance treatment

The American Journal of Drug and Alcohol Abuse
Sabine LoeberBernhard Croissant

Abstract

In the present study, we investigated whether buprenorphine as a partial mu-opioid receptor agonist is associated with less cognitive impairment than methadone. Neuropsychological functioning of opioid-dependent patients, previously assigned to methadone (MMP, n = 30) or buprenorphine (BMP, n = 26) maintenance treatment according to their own preference, was compared and dose effects were investigated. MMP and BMP performed equally well on all measures of neuropsychological functioning including the trail making test, the continuous performance test, and a vigilance task. However, patients receiving a higher dose of methadone were impaired in a vigilance task. In a free-choice administration of methadone or buprenorphine, there seems to be no difference in cognitive functioning. Possible explanations are discussed.

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Citations

Nov 6, 2009·Journal of Clinical and Experimental Neuropsychology·Allison J ApplebaumSteven A Safren
Apr 14, 2011·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Michael SoykaUNKNOWN WFSBP Task Force on Treatment, Guidelines for Substance Use Disorders
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Oct 2, 2009·Peptides·Richard J Bodnar
Jun 13, 2014·Journal of Psychopharmacology·Grace Y WangBruce R Russell
Nov 21, 2018·Psychological Medicine·A BaldacchinoK Matthews
Nov 5, 2019·Frontiers in Immunology·Aniella MurphyJoan W Berman
Jan 9, 2020·Harvard Review of Psychiatry·Caroline A BrowneIrwin Lucki
Mar 19, 2019·Frontiers in Psychiatry·Kevin Butler, Bernard Le Foll

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