Neuropsychological impairment and psychosis in mania

Journal of Clinical and Experimental Neuropsychology
Michael BassoRobert Bornstein

Abstract

Deficits involving executive function, working memory, speed of information processing, and new learning occur in many people with mania. Factors that predict impairment remain poorly understood, but there are indications that psychotic features may correspond with increased risk of neurocognitive dysfunction during manic episodes. The current study examined neuropsychological function in 40 inpatients with bipolar I mania, 24 of whom presented with psychotic features. Compared to a control group, the inpatients showed worse executive function, speed of information processing, new learning, and dexterity. Nonetheless, presence of psychotic features failed to distinguish the inpatients with mania. Thus, psychotic features do not appear to increase neurobehavioral morbidity in people with mania, but presence of mania clearly corresponded with neurobehavioral dysfunction. Implications of these data for clinical practice and our understanding of bipolar disorder are discussed.

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Citations

Aug 11, 2007·Cognitive Neuropsychiatry·Michael R BassoRobert Bornstein
Sep 22, 2009·Schizophrenia Bulletin·Emre BoraChristos Pantelis
Feb 3, 2016·Frontiers in Psychiatry·Rachel L C Mitchell, Allan H Young
Dec 3, 2015·Annals of General Psychiatry·Eirini Tsitsipa, Konstantinos N Fountoulakis
Mar 7, 2012·Journal of the International Neuropsychological Society : JINS·Lauren L DragLinas A Bieliauskas
Sep 29, 2020·Annals of General Psychiatry·Konstantinos N Fountoulakis
Mar 19, 2021·Revista colombiana de psiquiatría·Stephen Baena-OquendoCarlos López-Jaramillo

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Methods Mentioned

BETA
cognitive-behavioral therapy

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