To add to the open question whether cognitive impairments predict clinical outcome in schizophrenia, a sample of 125 first episode patients was assessed at the onset and over one year of controlled long-term treatment within a study of the German Research Network on Schizophrenia. No relapse according to predefined criteria occurred within the first year, but a total of 29 patients fulfilled post-hoc criteria of "clinical deterioration". Impairments in cognitive functioning assessed by the Trail-Making Test B at the onset of long-term treatment differentiated between patients with vs. without later clinical deterioration and proved to be a significant predictor of the clinical course in a regression analysis outperforming initial clinical status as predictor. However, low sensitivity (72%) and specificity (51%) limit possibilities of a transfer to individual predictions. As a linear combination of neuropsychological and psychopathological variables obtained highest predictive validity, such a combination may improve the prediction of the course of schizophrenic disorders and may ultimately lead to a more efficient and comprehensive treatment planning.
The Continuous Performance Test, identical pairs version (CPT-IP): I. New findings about sustained attention in normal families
Predictors of relapse following response from a first episode of schizophrenia or schizoaffective disorder
Cognitive dysfunction at baseline predicts symptomatic 1-year outcome in first-episode schizophrenics
Neurocognitive deficits and functional outcome in schizophrenia: are we measuring the "right stuff"?
Do specific neurocognitive deficits predict specific domains of community function in schizophrenia?
First vs multiple episode schizophrenia: two-year outcome of intermittent and maintenance medication strategies
A comparison of risperidone and haloperidol for the prevention of relapse in patients with schizophrenia
Neuropsychological change in young people at high risk for schizophrenia: results from the first two neuropsychological assessments of the Edinburgh High Risk Study
Longitudinal assessment of premorbid cognitive functioning in patients with schizophrenia through examination of standardized scholastic test performance
A prospective 2-year follow-up study of neurocognitive functioning in patients with first-episode schizophrenia
Neurocognitive function and outcome in first-episode schizophrenia: a 10-year follow-up of an epidemiological cohort
Pharmacological long-term treatment strategies in first episode schizophrenia--study design and preliminary results of an ongoing RCT within the German Research Network on Schizophrenia
Memory impairments identified in people at ultra-high risk for psychosis who later develop first-episode psychosis
Predictive values of neurocognition and negative symptoms on functional outcome in schizophrenia: a longitudinal first-episode study with 7-year follow-up
Ten year longitudinal study of neuropsychological functioning subsequent to a first episode of schizophrenia
Cognitive deficits in unaffected first-degree relatives of schizophrenia patients: a meta-analytic review of putative endophenotypes
Neuropsychological performance over time in people at high risk of developing schizophrenia and controls
The relationship between symptomatic remission and neuropsychological improvement in schizophrenia patients switched to treatment with ziprasidone
Predicting schizophrenia patients' real-world behavior with specific neuropsychological and functional capacity measures
Maintenance treatment with risperidone or low-dose haloperidol in first-episode schizophrenia: 1-year results of a randomized controlled trial within the German Research Network on Schizophrenia
Personalised medicine in psychiatry and psychotherapy. A review of the current state-of-the-art in the biomarker-based early recognition of psychoses
Cognitive remediation improves cognition and good cognitive performance increases time to relapse--results of a 5 year catamnestic study in schizophrenia patients
Cognitive behavioural therapy versus supportive therapy for persistent positive symptoms in psychotic disorders: the POSITIVE Study, a multicenter, prospective, single-blind, randomised controlled clinical trial
Cluster analysis of cognitive deficits may mark heterogeneity in schizophrenia in terms of outcome and response to treatment
Risk factors for relapse following treatment for first episode psychosis: a systematic review and meta-analysis of longitudinal studies
Predictors of early stable symptomatic remission after an exacerbation of schizophrenia: the significance of symptoms, neuropsychological performance and cognitive biases
The Longitudinal Course of Schizophrenia Across the Lifespan: Clinical, Cognitive, and Neurobiological Aspects
Cognitive Profiles and Functional Connectivity in First-Episode Schizophrenia Spectrum Disorders - Linking Behavioral and Neuronal Data
Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.