Neuropsychological, Neurovirological and Neuroimmune Aspects of Abnormal GABAergic Transmission in HIV Infection

Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology
Tetyana BuzhdyganB B Gelman

Abstract

The prevalence of HIV-associated neurocognitive disorders (HAND) remains high in patients with effective suppression of virus replication by combination antiretroviral therapy (cART). Several neurotransmitter systems were reported to be abnormal in HIV-infected patients, including the inhibitory GABAergic system, which mediates fine-tuning of neuronal processing and plays an essential role in cognitive functioning. To elucidate the role of abnormal GABAergic transmission in HAND, the expression of GABAergic markers was measured in 449 human brain specimens from HIV-infected patients with and without HAND. Using real-time polymerase chain reaction, immunoblotting and immunohistochemistry we found that the GABAergic markers were significantly decreased in most sectors of cerebral neocortex, the neostriatum, and the cerebellum of HIV-infected subjects. Low GABAergic expression in frontal neocortex was correlated significantly with high expression of endothelial cell markers, dopamine receptor type 2 (DRD2L), and preproenkephalin (PENK) mRNAs, and with worse performance on tasks of verbal fluency. Significant associations were not found between low GABAergic mRNAs and HIV-1 RNA concentration in the brain, the history of cART, or HI...Continue Reading

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Citations

Dec 20, 2017·Journal of Neurovirology·Benjamin B GelmanDennis Kolson
Nov 13, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Rowan SalonerMariana Cherner
Jan 9, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Elisa MantovaniStefano Tamburin
Feb 16, 2021·Cellular and Molecular Life Sciences : CMLS·Elena IrolloOlimpia Meucci
Aug 25, 2021·Current HIV/AIDS Reports·Susmita SilShilpa Buch

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Methods Mentioned

BETA
Dissection
PCR
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electrophoresis
gene array

Software Mentioned

ImageJ
LSM Image Browser
Olympus DP controller
Excel
GraphPad

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