Neuropsychological outcomes in adults commencing highly active anti-retroviral treatment in South Africa: a prospective study.

BMC Infectious Diseases
John A JoskaDan J Stein

Abstract

Infection with HIV may result in significant neuropsychological impairment, especially in late stage disease. To date, there have been no cohort studies of the impact of highly active anti-retroviral treatment (HAART) in South Africa where clade C HIV is predominant. Participants in the current study were recruited from a larger study of HIV-associated neurocognitive disorders (HAND) and included a group of individuals commencing HAART (n = 82). Baseline and one-year neuropsychological function was assessed using a detailed battery, and summary global deficit scores (GDS) obtained. Associations with change in GDS were calculated. Participants had a median CD4 cell count of 166 at baseline and 350 at follow-up. There were significant difference across groups of GDS severity at baseline with respect to level of education and GDS change at one year (p = 0.00 and 0.00 respectively). Participants with severe impairment at baseline improved significantly more than those with lesser degrees of impairment. Significant improvements were observed in the domains of attention, verbal fluency, motor function, and executive functions. There were unadjusted associations between GDS change and male gender, lower levels of education, baseline C...Continue Reading

References

May 1, 1995·Journal of the International Neuropsychological Society : JINS·R K HeatonR J Ellis
Jun 1, 1999·Journal of the International Neuropsychological Society : JINS·N R TemkinS S Dikmen
Nov 24, 1999·Journal of Neuropathology and Experimental Neurology·S F AnF Scaravilli
Apr 6, 2002·Journal of Neurovirology·Ned SacktorLeon Epstein
May 2, 2003·The Journal of Neuropsychiatry and Clinical Neurosciences·Stephen J FerrandoMartin McElhiney
Aug 27, 2003·Neurology·N SacktorUNKNOWN Multicenter AIDS Cohort Study (MACS)
Apr 21, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Kevin R RobertsonColin D Hall
May 14, 2004·HIV Medicine·J AminG J Dore
Oct 30, 2004·Journal of Clinical and Experimental Neuropsychology·Catherine L CareyUNKNOWN HNRC Group
Mar 4, 2005·Journal of Clinical and Experimental Neuropsychology·Ann B Shuttleworth-EdwardsSarah E Radloff
Nov 17, 2005·Annals of Internal Medicine·David B CliffordRoy M Gulick
Oct 26, 2006·Journal of Medical Virology·G B JacobsS Engelbrecht
Sep 13, 2007·Journal of Neurovirology·Kevin J LinerKevin R Robertson
Feb 2, 2008·International Review of Psychiatry·Avindra NathJustin McArthur
Feb 2, 2008·International Review of Psychiatry·Igor Grant
Mar 28, 2009·AIDS and Behavior·John A JoskaSoraya Seedat
May 9, 2009·AIDS·Christina M MarraUNKNOWN AIDS Clinical Trials Group 736 Study Team
May 9, 2009·Neuropsychology Review·Lucette A Cysique, Bruce J Brew

❮ Previous
Next ❯

Citations

Apr 5, 2013·Journal of the International Neuropsychological Society : JINS·Arpi MinassianUNKNOWN Translational Methamphetamine AIDS Research Center (TMARC) Group
Jun 28, 2014·BMC Public Health·Alain LekoubouAndre P Kengne
Nov 11, 2015·The Clinical Neuropsychologist·Jade A WittenJohn A Joska
Mar 12, 2016·Nature Reviews. Neurology·Deanna SaylorJustin C McArthur
Sep 20, 2015·Journal of the International AIDS Society·Olurotimi A AdejumoBabafemi O Taiwo
Oct 3, 2018·Continuum : Lifelong Learning in Neurology·Deanna Saylor
Dec 5, 2017·Journal of the International Neuropsychological Society : JINS·Rowan Saloner, Lucette A Cysique
Aug 15, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Dixon ChibandaMelanie Abas
May 3, 2019·The Clinical Neuropsychologist·Primrose NyamayaroHetta Gouse
Dec 14, 2018·Scientific Reports·Georgette D KanmogneRobert K Heaton
Nov 26, 2020·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Maral AghvinianReuben N Robbins
Jul 22, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Alyssa VecchioLeah H Rubin
Nov 13, 2020·The Journal of Antimicrobial Chemotherapy·Gilles ForceUNKNOWN NEURO+3 STUDY GROUP
Jul 21, 2020·International Journal of Nursing Sciences·Chang GaoHonghong Wang
Jul 10, 2021·Frontiers in Neurology·Antonio Spagnolo-Allende, Jose Gutierrez

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