Neuropsychological phenotypes among men with and without HIV disease in the multicenter AIDS cohort study

AIDS
Samantha A MolsberryNeuropsychology Working Group of the Multicenter AIDS Cohort Study

Abstract

Mild forms of HIV-associated neurocognitive disorder (HAND) remain prevalent in the combination antiretroviral therapy (cART) era. This study's objective was to identify neuropsychological subgroups within the Multicenter AIDS Cohort Study (MACS) based on the participant-based latent structure of cognitive function and to identify factors associated with subgroups. The MACS is a four-site longitudinal study of the natural and treated history of HIV disease among gay and bisexual men. Using neuropsychological domain scores, we used a cluster variable selection algorithm to identify the optimal subset of domains with cluster information. Latent profile analysis was applied using scores from identified domains. Exploratory and posthoc analyses were conducted to identify factors associated with cluster membership and the drivers of the observed associations. Cluster variable selection identified all domains as containing cluster information except for Working Memory. A three-profile solution produced the best fit for the data. Profile 1 performed below average on all domains, Profile 2 performed average on executive functioning, motor, and speed and below average on learning and memory, Profile 3 performed at or above average acros...Continue Reading

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Citations

May 21, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Raha M DastgheybNorman J Haughey
Jul 29, 2020·Journal of Neurovirology·Precious AmusanEsther Fujiwara
Mar 27, 2020·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Leah H RubinDionna W Williams
Dec 7, 2018·Journal of Neurovirology·Daniela GomezEsther Fujiwara
Jun 7, 2019·Current HIV/AIDS Reports·Robert Paul
Mar 9, 2021·Frontiers in Neurology·Raha M DastgheybLeah H Rubin
Aug 21, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Leah H Rubin, Beau M Ances

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