Abstract
Frontal lobe epilepsy (FLE) is the second most frequent type of localization-related epilepsy, and it may impact neurocognitive functioning with high variability. The prevalence of neurocognitive impairment in affected children remains poorly defined. This report outlines the neuropsychological profiles and outcomes in children with new onset FLE, and the impact of epilepsy-related factors, such as seizure frequency and antiepileptic drug (AED) load, on the neurocognitive development. Twenty-three consecutive children (15 males and 8 females) with newly diagnosed cryptogenic FLE were enrolled; median age at epilepsy onset was 7years (6-9.6years). They underwent clinical and laboratory evaluation and neuropsychological assessment before starting AED treatment (time 0) and after one year of treatment (time 1). Twenty age-matched patients affected by idiopathic generalized epilepsy (10 male and 10 females) and eighteen age-matched healthy subjects (9 males and 9 females) were enrolled as controls and underwent the same assessment. All patients with FLE showed a significant difference in almost all assessed cognitive domains compared with controls, mainly in frontal functions and memory. At time 1, patients were divided into two gr...Continue Reading
References
Oct 1, 1992·Neurology·M ManfordS D Shorvon
Dec 1, 1993·Neuropsychologia·I JambaquéJ L Signoret
Apr 6, 2002·Brain & Development·Kazue IgarashiHaruo Kashima
Dec 31, 2002·Journal of Child Neurology·Daria RivaSara Bulgheroni
Feb 11, 2003·Epilepsy Research·Melinda A NolanAnn M E Bye
Oct 7, 2003·Epilepsy & Behavior : E&B·Maria-Teresa HernandezMaryse Lassonde
Jul 12, 2005·NeuroImage·Francesca CormackTorsten Baldeweg
Jun 10, 2006·NeuroImage·N NelissenP Dupont
Jan 5, 2007·Epilepsia·Julie PrévostLionel Carmant
Sep 4, 2007·Pediatric Neurology·Patrícia RzezakKette D Valente
Aug 14, 2009·Neurology·P S FastenauD W Dunn
Nov 6, 2009·Epilepsia·Patrick KwanJacqueline French
Apr 13, 2011·Epilepsia·Hilde M H BraakmanAlbert P Aldenkamp
Jul 4, 2012·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Hilde M H BraakmanAlbert P Aldenkamp
Dec 21, 2012·Epilepsia·Hilde M H BraakmanWalter H Backes
Oct 12, 2013·Acta Neurologica Scandinavica·H M H BraakmanW H Backes
Mar 7, 2014·Frontiers in Neurology·Elizabeth N AndresenRobyn M Busch
Sep 12, 2014·Acta Neurologica Scandinavica·H M H BraakmanW H Backes
Citations
Feb 1, 2017·Current Opinion in Neurology·Kees P J Braun
May 28, 2019·Frontiers in Neurology·Zeinab GharaylouMahmoudreza Hadjighassem
Sep 4, 2020·Epilepsy & Behavior : E&B·Tamara P TavaresMary Lou Smith
Aug 11, 2019·Epilepsy & Behavior : E&B·Temitayo O Oyegbile
Mar 1, 2021·Epilepsy & Behavior : E&B·Borja Esteso OrduñaMaría Ángeles Pérez Jiménez
Apr 6, 2021·Brain and Language·Katharine BaileyNancie Im-Bolter