Jan 13, 1993

Neuropsychological sequelae of cardiac arrest

JAMA : the Journal of the American Medical Association
R O RoineM Kaste


Prospective and community-based studies on the cognitive outcome of out-of-hospital cardiac arrest have not been published. We studied prospectively the neuropsychological sequelae of cardiac arrest and evaluated the effects of nimodipine on them. Placebo-controlled, randomized, double-blind trial of nimodipine compared with placebo in out-of-hospital ventricular fibrillation. Urban area of 500,000 inhabitants served by the physician-manned Advanced Life Support Unit of Helsinki. A total of 155 successfully resuscitated consecutive patients out of 677 resuscitation attempts during 2 1/2 years. Sixty-eight survivors were examined by a neuropsychologist and a neurologist. Neuropsychological outcome 3 months and 1 year after cardiac arrest. Nimodipine or placebo at a dosage of 10 micrograms/kg as an intravenous injection immediately after restoration of spontaneous circulation, followed by an infusion of 0.5 micrograms/kg per minute for 24 hours. Three months after cardiac arrest, 41 (60%) of 68 patients were found to have moderate to severe cognitive deficits. At 12 months, 26 (48%) of 54 survivors still had moderate to severe deficits, and the Symptom Check List 90--Revised score indicated the presence of depression in 22 patien...Continue Reading

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Mentioned in this Paper

Ventricular Fibrillation
Intravenous Injections
Memory for Designs Test
Cognition Disorders
Regression Analysis
Subgroup A Nepoviruses
Incisors, Fused Mandibular

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