Neuropsychological underpinnings of the dynamics of bipolar disorder.

Epidemiology and Psychiatric Sciences
M WessaP Brambilla

Abstract

Although we have gained enormous insights into neurobiological and psychological underpinnings of bipolar disorder (BD) symptoms, our knowledge concerning pathogenic mechanisms initiating recurrent affective episodes is still fragmentary. Previous research has highlighted the role of significant life events and social rhythm in recurrent episodes of mania and depression. However, most studies share the drawback of retrospective self-report data, which are prone to recall biases and limited introspective abilities. Therefore, more objective data, such as neuropsychological and neurobiological measures are needed to further unravel the pathogenic mechanisms of the dynamics of bipolar disorder. Previous research has highlighted disturbed emotional reactivity as well as impaired emotion regulation and impulse control as major behavioural characteristics of BD and aberrancies in prefrontal-limbic-striatal networks that have been proposed to be the correlates of these behavioural alterations. However, longitudinal studies assessing these neural and behavioural alterations are rare. Future research should therefore adopt prospective study designs including behavioural and neuroimaging measures underlying cognitive, emotional and motiv...Continue Reading

References

Oct 4, 2003·Bipolar Disorders·Ellen Margrethe ChristensenEric Schaumburg
Apr 28, 2007·The Australian and New Zealand Journal of Psychiatry·Pilar SierraLuis Rojo
Nov 27, 2008·Journal of Affective Disorders·Diego J MartinoSergio Adrian Strejilevich
May 8, 2009·Bipolar Disorders·Alan C SwannF Gerard Moeller
May 19, 2010·Psychiatry Research·Rob HavermansMarten W deVries
Mar 17, 2012·Bipolar Disorders·Michael A CerulloStephen M Strakowski
Nov 20, 2012·Annual Review of Clinical Psychology·Timothy J Trull, Ulrich Ebner-Priemer
Dec 13, 2012·Journal of Affective Disorders·Diego J MartinoPablo Caravotta
Apr 23, 2013·Restorative Neurology and Neuroscience·Michèle WessaJulia Linke

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Citations

Sep 12, 2017·Journal of Basic Microbiology·Enikő BorosIstván Pócsi
Nov 17, 2015·Cancer Informatics·Nabila Bennani-Baiti, Idriss M Bennani-Baiti
Jan 1, 2016·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Peter Grindrod

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