Neuropsychology and neuroimaging profiles of amyloid-positive versus amyloid-negative amnestic mild cognitive impairment patients

Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring
Clémence TomadessoGaël Chételat

Abstract

Patients with amnestic mild cognitive impairment (aMCI) are heterogeneous as regard to their amyloid status. The present study aimed at highlighting the neuropsychological, brain atrophy, and hypometabolism profiles of amyloid-positive (Aβpos) versus amyloid-negative (Aβneg) aMCI patients. Forty-four aMCI patients and 24 Aβneg healthy controls underwent neuropsychological, structural magnetic resonance imaging and 18F-fluorodeoxyglucose positron emission tomography scans. Data were compared between groups in specific regions of interest and voxelwise with statistical parametric mapping. When directly comparing Aβpos to Aβneg aMCI, the former had lower performances in episodic memory tests (P = .02 to P < .001) while the latter had worse scores in working memory (P = .01) and language (P < .005). Compared to Aβneg healthy controls, both aMCI subgroups showed similar profiles of atrophy and hypometabolism, with no difference between both aMCI subgroups. In a sample of aMCI patients recruited and scanned in the same center, the main difference at baseline between Aβpos and Aβneg aMCI concerned the neuropsychological profile, but not the structural magnetic resonance imaging or 18F-fluorodeoxyglucose positron emission tomography pr...Continue Reading

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Citations

Feb 23, 2019·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Claire AndréGéraldine Rauchs
Jun 27, 2020·Journal of Neuropsychology·Luísa AlvesManuela Guerreiro
Apr 25, 2020·Journal of Personalized Medicine·Agostino ChiaravallotiOrazio Schillaci
May 10, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Zhihong ShiYong Ji
Jul 6, 2021·Brain Communications·Flavia LoretoParesh A Malhotra

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Clinical Trials Mentioned

NCT01638949

Software Mentioned

DARTEL
AlphaSim
VBM12
FreeSurfer
SPM12
Statistica
- SPM12

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