PMID: 18198473Jan 17, 2008Paper

Neuropsychotoxicity of abused drugs: effects of serotonin receptor ligands on methamphetamine- and cocaine-induced behavioral sensitization in mice

Journal of Pharmacological Sciences
Yukio AgoToshio Matsuda

Abstract

Repeated administration of psychostimulants elicits a progressive enhancement of locomotor activity known as behavioral sensitization. Central dopamine (DA) neurons play key roles as the neural substrates mediating behavioral sensitization, but the role of the serotonin (5-HT) system in the sensitization is not fully elucidated. We have recently demonstrated that osemozotan, a specific 5-HT(1A)-receptor agonist, and ritanserin, a 5-HT(2)-receptor antagonist, inhibited the expression and development of both methamphetamine- and cocaine-induced behavioral sensitization in mice and that these drugs attenuated the maintenance of behavioral sensitization of methamphetamine, but not that of cocaine. We also found that azasetron, a 5-HT(3)-receptor antagonist, inhibited the expression and development of the sensitization induced by methamphetamine and cocaine, respectively. Neurochemical studies using a microdialysis technique showed that repeated methamphetamine enhanced the methamphetamine-induced increase in 5-HT release in the prefrontal cortex. The sensitization of 5-HT release in methamphetamine-treated mice was attenuated by osemozotan and ritanserin. These findings suggest that the 5-HT system plays an important role in metham...Continue Reading

References

Dec 1, 1992·Pharmacology, Biochemistry, and Behavior·R B RothmanA Pert
Jun 11, 1993·European Journal of Pharmacology·T Hamamura, H C Fibiger
Aug 1, 1997·Pharmacology, Biochemistry, and Behavior·R J BlanchardD C Blanchard
Dec 24, 1997·Brain Research. Brain Research Reviews·R C Pierce, P W Kalivas
Aug 26, 1998·Drug and Alcohol Dependence·F J White, P W Kalivas
Aug 26, 1999·Neuropharmacology·N M Barnes, T Sharp
Mar 17, 2001·Nature Reviews. Neuroscience·E J Nestler
Jun 9, 2001·Behavioural Pharmacology·E PrzegalinskiJ Siwanowicz
Jun 30, 2001·European Journal of Pharmacology·E PrzegalinskiM Filip
May 6, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Karen K SzumlinskiPeter W Kalivas
May 8, 2004·The Journal of Pharmacology and Experimental Therapeutics·Malgorzata FilipKathryn A Cunningham
May 2, 2006·Proceedings of the National Academy of Sciences of the United States of America·Lucas SalomonJean-Pol Tassin
Sep 12, 2006·Pharmacology, Biochemistry, and Behavior·Yukio AgoToshio Matsuda
Sep 16, 2006·Journal of Pharmacological Sciences·Habib Abul MuntasirTakafumi Nagatomo

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Citations

May 24, 2014·Journal of Endocrinological Investigation·L ManettiA Ambrogio
Jun 22, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Takashi FutamuraTetsuro Kikuchi
Dec 17, 2010·CNS Neuroscience & Therapeutics·Takahide Shuto, Akinori Nishi
Jan 3, 2013·Psychiatry and Clinical Neurosciences·Mustafa GulecHalis Suleyman
May 12, 2010·Addiction Biology·Małgorzata FilipEdmund Przegaliński
May 3, 2011·Pharmacology, Biochemistry, and Behavior·Huma Ikram, Darakhshan Jabeen Haleem
Aug 26, 2010·Journal of Pharmacological Sciences·Yukihiro OhnoTadao Serikawa
May 7, 2016·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Toshio Matsuda
Jul 28, 2011·Izvestiia Akademii nauk. Seriia biologicheskaia·B N ManukhinL A Nesterova
Jan 21, 2021·Naunyn-Schmiedeberg's Archives of Pharmacology·Laila AsthFabrício A Moreira
Sep 25, 2010·Pharmacology, Biochemistry, and Behavior·Makoto MizunoHiroyuki Nawa
Aug 3, 2021·Frontiers in Pharmacology·Jia-Hao LiXiao-Li Xie
Apr 15, 2009·Current Opinion in Psychiatry

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