PMID: 18198471Jan 17, 2008Paper

Neuropsychotoxicity of abused drugs: potential of dextromethorphan and novel neuroprotective analogs of dextromethorphan with improved safety profiles in terms of abuse and neuroprotective effects

Journal of Pharmacological Sciences
Eun-Joo ShinHyoung-Chun Kim

Abstract

Drug abuse involving dextromethorphan, an antitussive, has been a social problem in various geographic locations since the 1960s. Ironically, high doses of the drug confer neuroprotective activity with central nervous system and behavioral effects. Accumulating evidence suggests that metabolism to phencyclidine-like dextrorphan is not essential for the neuroprotective activity of dextromethorphan. Here, we review the neuroprotective properties of dextromethorphan and its potential for abuse and the potential neuroprotective effects of the drug's analogs and 3-hydroxymorphinan, a metabolite of dextromethorphan. These compounds may provide a novel therapeutic direction for the treatment of neurodegenerative diseases such as convulsive or parkinsonian-like disorders.

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Citations

Nov 6, 2010·Archives of Pharmacal Research·Eun-Joo ShinHyoung-Chun Kim
Nov 18, 2009·Pharmacology & Therapeutics·Bianca Jupp, Andrew J Lawrence
May 4, 2011·Journal of Midwifery & Women's Health·Mary C Brucker, Tekoa L King
Aug 13, 2015·Journal of Psychoactive Drugs·George PringleKara I Gabriel
May 25, 2011·Journal of Pharmacological Sciences·Eun-Joo ShinHyoung-Chun Kim
Nov 3, 2016·Journal of Pharmacological Sciences·Hai-Quyen TranHyoung-Chun Kim
Aug 17, 2016·Biomedical Chromatography : BMC·Shihui BaoXianqin Wang
Nov 11, 2008·Annals of the New York Academy of Sciences·Joseph A Banken, Howell Foster
Feb 12, 2011·Analytical and Bioanalytical Chemistry·Ruri Kikura-HanajiriYukihiro Goda

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