PMID: 11902318Mar 21, 2002Paper

Neuroradiologic findings in focal cortical dysplasia: histologic correlation with surgically resected specimens

Epilepsia
K MatsudaK Yagi

Abstract

We investigated the neuroradiologic characteristics of focal findings of surgically resected specimens obtained from 47 patients with focal cortical dysplasia (FCD). Forty cases were detected by magnetic resonance imaging (MRI), and two cases were detected only by single-photon emission computed tomography (SPECT), but five cases could not be detected before operation. MRI revealed abnormal gyri and sulci in 34 patients (pachygyric in 18, polymicrogyric in 10, both in six), and blurring of the gray matter-white matter junction in 29 (72%) patients. Signal abnormalities were found in 36 (90%) patients, in the gray matter in 32, with white matter in 30, and at the gray matter-white matter junction in 13. Moreover, peculiar patterns of abnormal signals in the white matter were recognized, including remarkably abnormal subcortical signals of T2 hyperintensity and T1 hypointensity adjacent to the dysplastic cortex in 15 cases, high radiated T2 signals extending from the ependymal surface of the lateral ventricle to the overlying cortex in 11 cases, and widespread abnormal signals in the white matter with gray matter involvement in four cases. Histologically, these abnormal signals corresponded to various degrees of dyslamination and...Continue Reading

Citations

Apr 22, 2008·Neuro-Chirurgie·D MarnetC Daumas-Duport
Jun 11, 2005·Journal of the Neurological Sciences·Sonoko MisawaTakamichi Hattori
Oct 23, 2010·Epilepsy Research·Mitsugu UematsuShigeru Tsuchiya
Feb 24, 2016·Current Opinion in Neurology·Irene Wang, Andreas Alexopoulos
Jan 25, 2013·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Michael M HakkySami H Erbay
Feb 4, 2009·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Cormac OwensStephanie P Ryan
Oct 7, 2004·Journal of the Neurological Sciences·Sonoko MisawaTakamichi Hattori
Jun 24, 2008·Annals of Neurology·Pavel KrsekMichael Duchowny
Mar 24, 2011·AJR. American Journal of Roentgenology·Paul A M HofmanGraeme Jackson

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