Neurorehabilitation with neural transplantation.

Neurorehabilitation and Neural Repair
M D DöbrössyGuido Nikkhah

Abstract

Cell replacement therapy has been tested clinically in Parkinson's disease (PD) and Huntington's disease (HD), epilepsy, spinal cord injury, and stroke. The clinical outcomes have been variable, perhaps partly because of the differing levels of preclinical, basic experimental evidence that was available prior to the trials. The most promising results have been seen in PD trials, with encouraging ones in HD. A common feature of most trials is that they have concentrated on the biological and technical aspects of transplantation without presupposing that the outcomes might be influenced by events after the surgery. The growing evidence of plasticity demonstrated by the brain and grafts in response to environmental and training stimuli such as rehabilitation interventions has been mostly neglected throughout the clinical application of cell therapy. This review suggests that a different approach may be required to maximize recovery: postoperative experiences, including rehabilitation with explicit behavioral retraining, could have marked direct as well as positive secondary effects on the integration and function of grafted cells in the host neural system. The knowledge gained about brain plasticity following brain damage needs to...Continue Reading

References

Jan 1, 1992·Stereotactic and Functional Neurosurgery·M SramkaE Ruzický
Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·P J CoffeyJ N Rawlins
Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·H Klassen, R D Lund
Sep 1, 1993·Annals of Neurology·M GrabowskiB B Johansson
Feb 10, 1998·Experimental Neurology·O V KopyovK S Eagle
Apr 18, 1998·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·F LangH Völkl
Apr 29, 1998·Brain : a Journal of Neurology·T PlatzC D Marsden
Feb 2, 1999·Medicine and Science in Sports and Exercise·J A WoodsD C Nieman
Sep 1, 1999·Proceedings of the National Academy of Sciences of the United States of America·P J BrastedS B Dunnett
Jan 8, 2000·Stroke; a Journal of Cerebral Circulation·B B Johansson
May 18, 2000·Nature Neuroscience·A Björklund, O Lindvall
Jan 6, 2001·Progress in Brain Research·O Lindvall, P Hagell
Mar 10, 2001·The New England Journal of Medicine·C R FreedS Fahn
May 2, 2001·Nature Reviews. Neuroscience·S B DunnettO Lindvall
Dec 6, 2001·Nature Reviews. Neuroscience·M D Döbrössy, S B Dunnett
Jan 5, 2002·Journal of Rehabilitation Medicine·A NieuwboerY Kamsma
Sep 4, 2003·Annals of Neurology·C Warren OlanowThomas B Freeman
Nov 1, 1949·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·C O HEBB, H KONZETT
Jan 26, 2005·Trends in Neurosciences·Christian WinklerAnders Björklund
Feb 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Stephen B Dunnett, Anne E Rosser
Apr 7, 2005·Reviews in the Neurosciences·Màtè Daniel Döbrössy, Stephen B Dunnett
Aug 27, 2005·Journal of Neurosurgery·Douglas KondziolkaJeffrey Teraoka
Oct 6, 2005·Learning & Memory·Mariana AlonsoJorge H Medina
Nov 15, 2006·Annual Review of Medicine·Ilyas SingecEvan Y Snyder
Dec 13, 2006·The European Journal of Neuroscience·Máté D Döbrössy, Stephen B Dunnett
Jan 19, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·A NieuwboerI Lim
Mar 14, 2007·Brain Research Bulletin·Stephen B Dunnett, Anne E Rosser
Mar 27, 2007·Behavioural Brain Research·Máté D Döbrössy, Stephen B Dunnett

❮ Previous
Next ❯

Citations

May 13, 2011·Neuropsychological Rehabilitation·Giovanni Berlucchi
Apr 14, 2011·Cerebrovascular Diseases·Brigitte Onteniente, Jérôme Polentes
Nov 28, 2012·American Journal of Veterinary Research·Ji-Hey LimChristopher L Mariani
Sep 19, 2012·Nature Reviews. Neurology·Valentina TomassiniJacqueline Palace
Jan 10, 2012·Neuroscience and Biobehavioral Reviews·Alexander KleinStephen B Dunnett
Nov 28, 2012·Clinical Neurology and Neurosurgery·Ashu BhasinSushmita Bose
Jul 11, 2014·Frontiers in Neuroscience·Masahiro Yamaguchi, Kensaku Mori
Jan 20, 2012·Neurorehabilitation and Neural Repair·Alessandro PicelliNicola Smania
Oct 13, 2011·Neurorehabilitation and Neural Repair·Bruce H Dobkin, Andrew Dorsch
Sep 26, 2012·Cell Transplantation·Stephen Polgar
Sep 21, 2013·Cell Transplantation·UNKNOWN Chinese Branch of International Association of Neurorestoratology (IANR), UNKNOWN Preparatory Committee of Chinese Association of Neurorestoratology
Apr 12, 2018·Cell Transplantation·Hongyun HuangTong Li
Oct 19, 2013·Current Opinion in Neurology·Michel ModoLawrence R Wechsler

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.