Neuroscience of Adolescent Anorexia Nervosa: Implications for Family-Based Treatment (FBT)

Frontiers in Psychiatry
Roger Mysliwiec

Abstract

Over the past 20 years significant progress has been made to elucidate some of the neurobiological underpinnings of the development and maintenance of anorexia nervosa and their possible implications for treatment. There is increasing evidence supporting the notion that anorexia nervosa shares neurobehavioral patterns with anxiety disorders and involves reward processing aberrations and habit formation. There is consensus for the need of early intervention to ameliorate the effects of starvation on the adolescent brain and the effects of illness duration on neurodevelopment. Family-based treatment (FBT) is the first line evidence-based treatment for adolescents with anorexia nervosa achieving sustainable full remission rates of over 40%. FBT has an agnostic treatment approach and its mechanisms of change have until now not been fully understood. To help fill this gap in theoretical understanding, this paper will provide a review of the treatment model of FBT through a neuroscientific lens. It argues that FBT is well designed to address the implications of current key findings of the neuroscience of anorexia nervosa and that it is also well aligned with the current understanding of neuroscience principles underpinning therapeuti...Continue Reading

References

Aug 3, 2002·The American Journal of Psychiatry·Hans-Christoph Steinhausen
Sep 30, 2003·Cellular and Molecular Neurobiology·Joseph LeDoux
Apr 22, 2004·The International Journal of Eating Disorders·Michael Strober
Nov 2, 2004·The British Journal of Psychiatry : the Journal of Mental Science·D A Collier, J L Treasure
Dec 1, 2004·The American Journal of Psychiatry·Walter H KayeKim Masters
Apr 27, 2005·The International Journal of Eating Disorders·Stephen A WonderlichJames E Mitchell
Aug 9, 2008·Developmental Review : DR·B J CaseyAdriana Galvan
May 19, 2009·The American Journal of Psychiatry·Rachel MarshBradley S Peterson
May 21, 2009·Nature Reviews. Neuroscience·Amy F T Arnsten
Jul 16, 2009·Nature Reviews. Neuroscience·Walter H KayeMartin Paulus
Jul 2, 2011·The British Journal of Psychiatry : the Journal of Mental Science·Janet Treasure, Gerald Russell
Dec 17, 2011·Behaviour Research and Therapy·Daniel Le GrangeHelena C Kraemer
Jan 10, 2012·European Eating Disorders Review : the Journal of the Eating Disorders Association·Tom HildebrandtKatharine L Loeb
Mar 1, 2012·Neuroscience and Biobehavioral Reviews·Brendan E Depue
Apr 12, 2012·European Eating Disorders Review : the Journal of the Eating Disorders Association·Megan E ShottGuido K W Frank
Jan 22, 2013·Trends in Neurosciences·Walter H KayeAmanda Bischoff-Grethe
Feb 23, 2013·The American Journal of Psychiatry·B Timothy Walsh
Aug 22, 2013·Current Psychiatry Reports·Guido K W Frank
Sep 26, 2013·Current Opinion in Psychiatry·Frédérique R E SminkHans W Hoek
Feb 4, 2014·The International Journal of Eating Disorders·Joanna E SteinglassB Timothy Walsh
Apr 2, 2014·The American Journal of Psychiatry·Thomas R Insel
Jun 4, 2014·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Edward ChesneySeena Fazel
Mar 17, 2015·Current Psychiatry Reports·Jennifer E Wildes, Marsha D Marcus
Jul 28, 2015·The Cochrane Database of Systematic Reviews·Phillipa J HayGhada Abd Elbaky
Oct 9, 2015·Neuron·Joseph E DunsmoorElizabeth A Phelps
Mar 26, 2016·World Journal of Psychiatry·Beatriz Martin MonzonStephen Touyz
Jul 28, 2016·JAMA Psychiatry·Stuart B MurrayDaniel Le Grange
Sep 1, 2016·Behaviour Research and Therapy·Stuart B MurrayDaniel Le Grange
Dec 17, 2016·Journal of Eating Disorders·Laura HillWalter H Kaye
Jan 20, 2017·Neuron·Roger A Nicoll
Feb 25, 2017·The American Journal of Psychiatry·Marisa DeGuzmanGuido K W Frank
Apr 11, 2017·The International Journal of Eating Disorders·Karin Foerde, Joanna E Steinglass
Sep 19, 2017·Nature Neuroscience·Akira UematsuJoshua P Johansen
Dec 8, 2017·Journal of Eating Disorders·Lasse BangAndreas Joos
Jul 22, 2018·JAMA Psychiatry·Joanna E Steinglass, Karin Foerde
Jul 25, 2018·Current Psychiatry Reports·Blair UniackeJoanna Steinglass
Sep 4, 2018·Current Neuropharmacology·Stephan Zipfel, Ulrike Schmidt
Oct 18, 2018·European Eating Disorders Review : the Journal of the Eating Disorders Association·Carol KanJanet Treasure
Nov 13, 2018·Frontiers in Systems Neuroscience·Jesse J Langille, Richard E Brown

❮ Previous
Next ❯

Methods Mentioned

BETA
Deep Brain Stimulation

Software Mentioned

MANTRA

Related Concepts

Related Feeds

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.