Neuroscience of learning and memory for addiction medicine: from habit formation to memory reconsolidation

Progress in Brain Research
Mary M Torregrossa, Jane R Taylor

Abstract

Identifying effective pharmacological treatments for addictive disorders has remained an elusive goal. Many different classes of drugs have shown some efficacy in preclinical models, but the number of effective clinical therapeutics has remained stubbornly low. The persistence of drug use and the high frequency of relapse is at least partly attributable to the enduring ability of environmental stimuli associated with drug use to maintain behavioral patterns of drug use and induce craving during abstinence. We propose that stimuli associated with drug use exert such powerful control over behavior through the development of abnormally strong memories, and their ability to initiate subconscious sequences of motor actions (habits) that promote uncontrolled drug use. In this chapter, we will review the evidence suggesting that drugs of abuse strengthen associations with cues in the environment and facilitate habit formation. We will also discuss potential mechanisms for disrupting memories associated with drug use to help improve treatments for addiction.

Citations

Aug 24, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rita A Fuchs, Ryan J McLaughlin
Jul 7, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Melissa S MonseyJane R Taylor
Dec 4, 2019·Nature Neuroscience·William J WrightYan Dong
Mar 4, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Elizabeth V GoldfarbRajita Sinha
Jan 31, 2020·Frontiers in Behavioral Neuroscience·Melissa S MonseyJane R Taylor
Jan 15, 2020·Neuroscience and Biobehavioral Reviews·Caroline CorreiaKatia Befort
Nov 3, 2020·Frontiers in Behavioral Neuroscience·Greer McKendrick, Nicholas M Graziane
Nov 14, 2016·Neurobiology of Learning and Memory·Amber B Dunbar, Jane R Taylor
Sep 2, 2018·Trends in Neurosciences·Elizabeth V Goldfarb, Rajita Sinha
May 22, 2021·Journal of Substance Abuse Treatment·Thomas ZandonaiCristiano Chiamulera
Aug 7, 2021·Addictive Behaviors·Kavinash Loganathan

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