Neurostimulant Prescribing Patterns in Children Admitted to the Intensive Care Unit after Traumatic Brain Injury

Journal of Neurotrauma
Amanda MorrisonEricka Fink

Abstract

Neurostimulant medications are commonly prescribed following traumatic brain injury (TBI) in adults; little is known about their use in children with TBI. Our objective was to analyze neurostimulant prescribing practices from 2005 to 2015 in children admitted to the intensive care unit (ICU) with TBI. We hypothesized that neurostimulant prescriptions have increased over time and are associated with older age and injury severity. A retrospective cohort study of patients age 1 month to 18 years with an International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) discharge diagnosis code for TBI admitted to the ICU between 2005 and 2015 in 37 pediatric hospitals included in the Pediatric Health Information System was conducted. Variables examined include patient and injury characteristics and neurostimulant medication use. Descriptive statistics and multi-variable logistic regression testing were used to determine variables associated with neurostimulant prescription. Of 30,881 patients with TBI, most were male (64%) and age 0-4 years (43%). In patients with mechanism of injury reported (n = 21,998), TBI was most frequently due to falls (36%) and motor vehicle collisions (36%). One thousand sixty-four...Continue Reading

References

Apr 16, 1985·European Journal of Pharmacology·G GianutsosJ P Dunn
Jan 1, 1997·Journal of Neurophysiology·T A BlanpiedJ W Johnson
Jun 17, 1998·Journal of the American Academy of Child and Adolescent Psychiatry·J P GerringM B Denckla
Oct 2, 1998·Brain Injury : [BI]·Z GroswasserO Keren
Jul 6, 2004·The Journal of Biological Chemistry·Lina DuRobert S B Clark
Dec 31, 2004·American Journal of Physical Medicine & Rehabilitation·Liza B GreenEdward A Hurvitz
Mar 4, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Margaret A SatchellRobert S B Clark
Apr 14, 2005·Archives of Physical Medicine and Rehabilitation·Sydney A RiceDouglas P Wagner
Sep 20, 2005·The Journal of Head Trauma Rehabilitation·Sue R BeersPhilip David Adelson
Sep 29, 2006·Journal of Child Neurology·Peter D PatrickMark R Conaway
Aug 31, 2007·Brain Injury : [BI]·Sharon E Williams
Jan 24, 2008·The Annals of Pharmacotherapy·Elizabeth SawyerMartin J Ohlinger
Jan 27, 2009·Brain : a Journal of Neurology·Vicki AndersonRani Jacobs
Feb 24, 2009·Journal of Pediatric Surgery·Joseph J TepasBrian G Celso
May 1, 2009·American Journal of Physical Medicine & Rehabilitation·Mary A McMahonJudy Bean
Nov 11, 2009·The Journal of Trauma·Cherisse BerryAli Salim
Jan 28, 2010·Journal of Rehabilitation Research and Development·Effie Chew, Ross D Zafonte
Feb 5, 2010·PM & R : the Journal of Injury, Function, and Rehabilitation·Jilda N Vargus-AdamsAlexander A Vinks
Mar 2, 2012·The New England Journal of Medicine·Joseph T GiacinoMark Sherer
May 23, 2012·The Journal of Head Trauma Rehabilitation·Cara Camiolo ReddyAnthony P Kontos
May 29, 2012·Pediatric Neurology·Anne L Gordon, Annalisa di Maggio
Mar 12, 2013·Archives of Physical Medicine and Rehabilitation·Tellen D BennettSusan L Bratton
Jul 19, 2013·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Michael J BellUNKNOWN Multiple Medical Therapies for Pediatric Traumatic Brain Injury Workgroup
Dec 3, 2014·Journal of Pediatric Health Care : Official Publication of National Association of Pediatric Nurse Associates & Practitioners·Myra L PopernackKarin Reuter-Rice
Feb 24, 2015·Handbook of Clinical Neurology·Louise M CroweVicki Anderson
Jul 28, 2015·Archives of Physical Medicine and Rehabilitation·Flora M HammondSusan D Horn
Feb 3, 2016·Archives of Physical Medicine and Rehabilitation·Vincy ChanAngela Colantonio
Oct 21, 2016·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Beth WieczorekSapna R Kudchadkar

❮ Previous
Next ❯

Citations

Aug 8, 2019·Current Opinion in Pediatrics·Ian C Coulter, Rob J Forsyth
Nov 7, 2019·Current Opinion in Pediatrics·Ian C Coulter, Rob J Forsyth
Sep 1, 2021·The Journal of Surgical Research·Brett M TracyRondi B Gelbard

❮ Previous
Next ❯

Software Mentioned

Stata

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.