Neurotensin Changes Propulsive Activity into a Segmental Motor Pattern in the Rat Colon

Journal of Neurogastroenterology and Motility
Hongfei LiJan D Huizinga

Abstract

Neurotensin is a gut-brain peptide with both inhibitory and excitatory actions on the colonic musculature; our objective was to understand the implications of this for motor patterns occurring in the intact colon of the rat. The effects of neurotensin with concentrations ranging from 0.1-100 nM were studied in the intact rat colon in vitro, by investigating spatio-temporal maps created from video recordings of colonic motility before and after neurotensin. Low concentration of neurotensin (0.1-1 nM) inhibited propagating long distance contractions and rhythmic propagating motor complexes; in its place a slow propagating rhythmic segmental motor pattern developed. The neurotensin receptor 1 antagonist SR-48692 prevented the development of the segmental motor pattern. Higher concentrations of neurotensin (10 nM and 100 nM) were capable of restoring long distance contraction activity and inhibiting the segmental activity. The slow propagating segmental contraction showed a rhythmic contraction-- relaxation cycle at the slow wave frequency originating from the interstitial cells of Cajal associated with the myenteric plexus pacemaker. High concentrations given without prior additions of low concentrations did not evoke the segmenta...Continue Reading

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Citations

Aug 11, 2018·American Journal of Physiology. Gastrointestinal and Liver Physiology·Alexander D VincentJan D Huizinga
Apr 24, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Mitra ShokrollahiJan D Huizinga
Oct 31, 2017·BioMed Research International·Giuseppe RiezzoFrancesco Russo

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