Neurotensin facilitates release of substance P in the guinea-pig inferior mesenteric ganglion.

The Journal of Physiology
W H Stapelfeldt, J H Szurszewski

Abstract

1. Intracellular, electrophysiological techniques were combined with radio-immunological, chromatographic and pharmacological techniques to determine if nerve terminals containing substance P mediated transient depolarizing responses of principal ganglion cells induced by neurotensin. Experiments were performed in vitro on guinea-pig inferior mesenteric ganglia. 2. In 61% of principal ganglion cells tested in normal ganglia, neurotensin caused a transient membrane depolarization. In ganglia which were removed from animals which had been pre-treated with capsaicin, transient responses to neurotensin were virtually abolished. 3. In normal ganglia, neurotensin increased the amplitude and duration of noncholinergic slow EPSPs evoked by electrical stimulation of the lumbar colonic nerve. Such increases were absent in ganglia obtained from animals pre-treated with capsaicin. 4. In guinea-pigs pre-treated with capsaicin, the content of substance P-like material was significantly reduced in inferior mesenteric and coeliac ganglia, dorsal root ganglia and lumbar spinal cord, compared to control animals. The content of substance P-like material in segments of distal colon was slightly reduced. The content of vasoactive intestinal polypep...Continue Reading

Citations

Sep 12, 2000·European Journal of Pharmacology·S KawaradaS Komori
Jul 5, 1996·Journal of the Autonomic Nervous System·E J Parr, K A Sharkey
Jan 1, 1994·Journal of the Autonomic Nervous System·J B Furness, C R Anderson
Apr 1, 1991·Journal of the Autonomic Nervous System·C A Maggi
Sep 28, 1998·Pharmacology & Therapeutics·E Hermans, J M Maloteaux
Jan 1, 1992·Annals of the New York Academy of Sciences·W X Shi, B S Bunney
May 1, 1990·Journal of Neurochemistry·E W KristensenG M Tyce
Jul 31, 2004·The Journal of Physiology·Leonid G ErmilovJoseph H Szurszewski
Oct 1, 1992·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·W Kummer
Feb 25, 2006·The Journal of Comparative Neurology·Yasmin NasserKeith A Sharkey
Jun 1, 1991·Journal of Autonomic Pharmacology·C A Maggi
Mar 17, 1999·The Journal of Clinical Investigation·I CastagliuoloC Pothoulakis
Jul 1, 2020·Journal of Anatomy·Martin M BertrandJanet R Keast
Jan 1, 1997·Pharmacology & Therapeutics·P Holzer, U Holzer-Petsche

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.