Neurotensin inversely modulates maternal aggression.

Neuroscience
Stephen C GammieSharon A Stevenson

Abstract

Neurotensin (NT) is a versatile neuropeptide involved in analgesia, hypothermia, and schizophrenia. Although NT is released from and acts upon brain regions involved in social behaviors, it has not been linked to a social behavior. We previously selected mice for high maternal aggression (maternal defense), an important social behavior that protects offspring, and found significantly lower NT expression in the CNS of highly protective females. Our current study directly tested NT's role in maternal defense. Intracerebroventricular (i.c.v.) injections of NT significantly impaired defense in terms of time aggressive and number of attacks at all doses tested (0.05, 0.1, 1.0, and 3.0 microg). Other maternal behaviors, including pup retrieval, were unaltered following NT injections (0.05 microg) relative to vehicle, suggesting specificity of NT action on defense. Further, i.c.v. injections of the NT receptor 1 (NT1) antagonist, SR 48692 (30 microg), significantly elevated maternal aggression in terms of time aggressive and attack number. To understand where NT may regulate aggression, we examined Fos following injection of either 0.1 microg NT or vehicle. Thirteen of 26 brain regions examined exhibited significant Fos increases with...Continue Reading

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Citations

Apr 23, 2013·Cell and Tissue Research·Laura M HuckinsGabriela Sánchez-Andrade
Dec 17, 2009·Behavioral Neuroscience·Grace Lee, Stephen C Gammie
May 11, 2011·Hormones and Behavior·Melissa-Ann L ScottiStephen C Gammie
Aug 1, 2014·Genes, Brain, and Behavior·M Angoa-PérezD M Kuhn
Dec 6, 2011·Brain Research·Stephen C GammieGriffin M Gessay
Mar 26, 2013·Current Diabetes Reports·Janet K Snell-BergeonJohn E Hokanson
Nov 20, 2019·Neuropeptides·Nicola J LeeHerbert Herzog
Feb 15, 2020·Neuropharmacology·María Luisa Torruella-Suárez, Zoe A McElligott

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