PMID: 7516053Mar 1, 1994Paper

Neurotensin modulates cholinergic and noncholinergic neurotransmission in guinea-pig main bronchi in vitro

Neuropeptides
C A MartinC Advenier

Abstract

Guinea-pig main bronchi were stimulated transmurally in vitro by electrical field stimulation in the presence of indomethacin 10(-6) M, propranolol 10(-6) M and phosphoramidon 10(-5) M. Two contractile neurogenic responses were successively observed. The second noncholinergic contraction was concentration dependently inhibited or abolished by neurotensin whereas the first cholinergic contraction was only partially inhibited. SR 48692, a novel antagonist of neurotensin receptors, reduced the inhibition induced by neurotensin (pKB = 9.75) whereas levocabastine, an antagonist of low-affinity neurotensin receptors, did not significantly modify the inhibitory effects of neurotensin on both neurally-mediated contractions. These results demonstrate that neurotensin exerts an inhibitory effect on neurotransmission in guinea-pig airways. Furthermore, the present study shows that the newly developed neurotensin receptors antagonist, SR 48692, is a potent inhibitor of the neurotensin inhibitory effects on cholinergic and noncholinergic contractions induced by electrical field stimulation of the guinea-pig isolated main bronchus.

References

Feb 15, 1979·European Journal of Pharmacology·B V ClineschmidtP B Bunting
Jan 1, 1992·Annals of the New York Academy of Sciences·J P Vincent
Nov 1, 1991·The American Review of Respiratory Disease·P J BarnesM G Belvisi
Mar 1, 1991·The American Review of Respiratory Disease·P J Barnes
Aug 1, 1991·The American Review of Respiratory Disease·C A MaggiP Santicioli
Dec 1, 1991·The American Review of Respiratory Disease·P J BarnesM G Belvisi
Oct 1, 1990·Journal of Applied Physiology·B J UndemD Weinreich
May 1, 1989·Journal of Applied Physiology·T D DjokicJ A Nadel
Feb 1, 1987·The Journal of Allergy and Clinical Immunology·P J Barnes
Feb 1, 1987·Naunyn-Schmiedeberg's Archives of Pharmacology·T P Kenakin, D Beek
Feb 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·J M LundbergK Folkers
May 1, 1982·Regulatory Peptides·P Aas, K B Helle
Mar 1, 1982·Acta Physiologica Scandinavica·P G KrügerK B Helle
Jan 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D GullyA Brouard
Mar 1, 1959·British Journal of Pharmacology and Chemotherapy·O ARUNLAKSHANA, H O SCHILD

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Citations

Jul 24, 2012·European Journal of Pharmacology·Katarzyna Kaczyńska, Małgorzata Szereda-Przestaszewska
Oct 17, 2019·International Journal of Molecular Sciences·Ewelina Russjan, Katarzyna Kaczyńska
Apr 15, 2021·Clinical and Experimental Pharmacology & Physiology·Ewelina RussjanKatarzyna Kaczyńska

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