PMID: 9527117Apr 4, 1998Paper

Neurotic effects of doxycycline sclerotherapy

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
D J KirseR F Schaefer

Abstract

A patient experienced phrenic nerve paralysis after doxycycline sclerotherapy for treatment of chylous fistula at our institution. The purpose of this study is to use physiologic testing to determine whether doxycycline is capable of inducing defects in neural function. A nonrandomized, controlled trial was performed with nerve-conduction studies to determine possible deleterious effects of doxycycline sclerotherapy. Thirty-eight CD rats were used and separated into four groups. Doxycycline was applied to the sciatic nerves of rats by either topical application directly on the nerve or by intraneural injection. Nerve-conduction studies were done before surgery and at 1,7, and 21 days after surgery. The results showed a statistically significant decrement in nerve-conduction velocity and strength of transmitted impulse in those nerves injected with doxycycline solution. Complete nerve block was seen frequently. This effect was not seen with topical application of doxycycline or normal saline solution or with intraneural injection of normal saline solution. This study demonstrates that doxycycline can induce a marked decrement in neural function when applied to the subepineural layers of the sciatic nerve in the rat. Therefore do...Continue Reading

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Citations

Dec 20, 2008·Lymphatic Research and Biology·Patricia E BurrowsJohn B Mulliken
May 20, 2015·Journal of Pediatric Orthopedics·William E ShielsJoel L Mayerson
Feb 8, 2011·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Andrei IlczyszynAmer J Durrani
Jan 25, 2011·Auris, Nasus, Larynx·Dunia Abdul-AzizDaniel G Deschler
Dec 7, 2007·Gastrointestinal Endoscopy·Shou-Jiang TangPhillip D Purdy
Aug 13, 2013·International Journal of Pediatric Otorhinolaryngology·Kevin L WangCecille G Sulman
Jan 12, 2000·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·B NussenbaumR J Sinard

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