Neuroticism and serotonin 5-HT1A receptors in healthy subjects

Psychiatry Research
Jussi HirvonenJarmo Hietala

Abstract

Neuroticism is a personality trait associated with vulnerability for mood and anxiety disorders. Serotonergic mechanisms likely contribute to neuroticism. Serotonin 5-HT1A receptors are altered in mood and anxiety disorders, but whether 5-HT1A receptors are associated with neuroticism in healthy subjects is unclear. We measured brain serotonin 5-HT1A receptor in 34 healthy subjects in vivo using positron emission tomography (PET) and [carbonyl-(11)C]WAY-100635. Binding potential (BPP) was determined using the golden standard of kinetic compartmental modeling using arterial blood samples and radiometabolite determination. Personality traits were assessed using the Karolinska Scales of Personality. We found a strong negative association between serotonin 5-HT1A receptor BPP and neuroticism. That is, individuals with high neuroticism tended to have lower 5-HT1A receptor binding than individuals with low neuroticism. This finding was confirmed with an independent voxel-based whole-brain analysis. Other personality traits did not correlate with 5-HT1A receptor BPP. Previous observations have reported lower serotonin 5-HT1A receptor density in major depression. This neurobiological finding may be a trait-like phenomenon and partly ex...Continue Reading

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Citations

Jan 19, 2016·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Jani PenttiläJarmo Hietala
Apr 21, 2016·Schizophrenia Research·Verônica M Saia-CeredaDaniel Martins-de-Souza
Apr 25, 2018·Nordic Journal of Psychiatry·Anu AluojaEduard Maron
Oct 12, 2017·The International Journal of Neuropsychopharmacology·Lauri TuominenJarmo Hietala
Feb 28, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Lars FardeSimon Cervenka
Feb 19, 2020·Current Topics in Medicinal Chemistry·Valérie ZuffereyFerath Kherif
Aug 27, 2019·Brain and Behavior·Ángel Rodríguez-RamosManuel Ruiz-Rubio
Oct 3, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Martin NørgaardGitte M Knudsen

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