Neuroticism polygenic risk score predicts 20-year burden of depressive symptoms for Whites but not Blacks

Journal of Medical Research and Innovation
Shervin AssariJennifer A Smith

Abstract

Black-White differences are reported in social, psychological, behavioral, medical, and biological correlates of depression. This study was conducted to compare Black and White older adults for the association between neuroticism polygenic risk score (N-PRS) and chronicity of depressive symptoms over 20 years. Data came from the Health and Retirement Study (HRS), 1990 - 2012, a nationally representative sample of Americans above age 50. Current analysis followed 9,249 individuals (7,924 Whites and 1,325 Blacks) for up to 22 years. Depressive symptoms were measured every two years between 1992 and 2012 using the 8-item Center for Epidemiological Studies-Depression Scale (CES-D-8). The independent variable was N-PRS. The dependent variable was average depressive symptoms between 1992 and 2012. Linear regression was used for data analysis. In the pooled sample, higher N-PRS was associated with higher average depressive symptoms over the 20-year follow up period [b=0.01, 95%CI=0.00 to 0.04], net of all covariates. We also found an interaction between race and N-PRS [b=-0.02, 95%CI=-0.03 to 0.00], suggesting a stronger effect of N-PRS on 20-year average depressive symptoms for Whites than Blacks. Based on our race-specific linear re...Continue Reading

References

Sep 1, 1992·Psychological Bulletin·B Mesquita, N H Frijda
Apr 1, 1980·Journal of Personality and Social Psychology·P T Costa, R R McCrae
Jun 1, 1994·Journal of Personality and Social Psychology·D Derryberry, M A Reed
Feb 24, 2001·Journal of Personality and Social Psychology·B Mesquita
Aug 2, 2002·The British Journal of Psychiatry : the Journal of Mental Science·Anne FarmerPeter McGuffin
Feb 18, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Srijan SenMargit Burmeister
Feb 24, 2006·Journal of Abnormal Psychology·Edward J WilsonElizabeth M Rutherford
Jun 28, 2006·Australian and New Zealand Journal of Public Health·Anne W TaylorRichard E Ruffin
Jul 5, 2006·Archives of General Psychiatry·Gregory E SimonRonald C Kessler
Dec 6, 2006·Journal of Personality and Social Psychology·Christie Napa Scollon, Ed Diener
Feb 11, 2009·The American Psychologist·Randolph M Nesse, Phoebe C Ellsworth
May 20, 2009·The American Psychologist·Benjamin B Lahey
Jun 2, 2009·Journal of the American Geriatrics Society·Giyeon KimYuri Jang
Dec 8, 2009·American Journal of Epidemiology·Benjamin P ChapmanPaul R Duberstein
Jan 15, 2010·Behaviour Research and Therapy·Thorsten Barnhofer, Tobias Chittka
Mar 18, 2010·The Journal of Head Trauma Rehabilitation·Juan Carlos Arango-Lasprilla, Jeffrey S Kreutzer
Jul 28, 2010·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Yuri JangDavid A Chiriboga
Apr 28, 2011·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Giyeon KimPatricia Parmelee
Mar 16, 2012·Journal of Health Psychology·Jiyoung ParkCarol D Ryff
Nov 6, 2012·Brain, Behavior, and Immunity·Nicholas A TurianoBenjamin P Chapman
Nov 14, 2012·International Journal of Methods in Psychiatric Research·Jennifer Greif GreenMargarita Alegria
May 11, 2013·Journal of Women's Health·Margaret T HickenJames S Jackson
Feb 25, 2014·Journal of Research in Personality·Catharine R GaleIan J Deary
Mar 29, 2014·International Journal of Epidemiology·Amanda SonnegaDavid R Weir
Jan 30, 2016·Journal of Racial and Ethnic Health Disparities·Shervin AssariAmanda Leggett
Feb 11, 2016·Journal of Racial and Ethnic Health Disparities·Daphne C WatkinsVicki Johnson-Lawrence
Feb 11, 2016·Journal of Racial and Ethnic Health Disparities·Shervin Assari, Cleopatra Howard Caldwell
Mar 1, 2016·Frontiers in Public Health·Ehsan Moazen-Zadeh, Shervin Assari
Mar 26, 2016·Frontiers in Public Health·Shervin AssariValerie Micol-Foster
Apr 6, 2016·Frontiers in Public Health·Shervin Assari, Maryam Moghani Lankarani
May 6, 2016·Frontiers in Public Health·Shervin Assari, Maryam Moghani Lankarani

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