Neurotoxic effect of triazophos on goldfish (Carassius auratus) and tissue specific antioxidant responses

Ecotoxicology and Environmental Safety
Lei LiuGao-Xue Wang

Abstract

Due to the high chemical and photochemical stability, an organophosphorus pesticide triazophos might enter aquatic ecosystems and impose negative effect on aquatic organisms. In order to investigate short-term toxicity of triazophos on goldfish (Carassius auratus), antioxidant response in brain, spleen, kidney and liver was tested in this study. As a confirmation, the impact of triazophos on acetyl cholinesterase (AChE) activity was found a reduction in all studied tissues, especially in brain. In addition, 0.1 and 0.5 mg L(-1) triazophos induced MDA level increased, while glutathione content (GSH), superoxide dismutase (SOD), catalase (CAT) and lactate dehydrogenase (LDH) activities decreased. Of note, more prominent oxidative stress was provoked in kidney and liver, but weaker in brain and spleen. These results revealed that triazophos could cause a generalized oxidative stress and tissue specific antioxidant response in goldfish. Furthermore, neuroendocrine-growth-related gene expression (growth hormone (GH), luteinizing hormone (LH) and peptide YY) in brain was also changed by exposed to triazophos during 4 and 7d exposure periods. Linked with the above results, the present study pointed out that triazophos might induce a n...Continue Reading

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Citations

Sep 20, 2020·Bulletin of Environmental Contamination and Toxicology·Özgür Fırat, Ramazan Tutus
Oct 13, 2018·Toxicology Research·Longlue JiaJiangfeng Guo
Feb 20, 2021·Drug and Chemical Toxicology·Ajay Kumar BhardwajManish Kumar Tripathi
Mar 17, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Rakesh Kumar ChandraManish Kumar Tripathi
Sep 10, 2020·Environmental Science & Technology·Jason MagnusonDaniel Schlenk

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