PMID: 12769188May 29, 2003Paper

Neurotoxicity of acetaldehyde-derived advanced glycation end products for cultured cortical neurons

Journal of Neuropathology and Experimental Neurology
Masayoshi TakeuchiYukihiko Kameda

Abstract

The Maillard reaction that leads to the formation of advanced glycation end products (AGEs) plays an important role in the pathogenesis of angiopathy in diabetic patients, in aging, and in neurodegenerative processes. We hypothesize that acetaldehyde (AA), one of the main metabolites of alcohol, may be involved in alcohol-induced neurotoxicity in vivo by formation of AA-derived AGEs (AA-AGEs) with brain proteins. Incubation of cortical neurons with AA-AGE produced a dose-dependent increase in neuronal cell-death, and the neurotoxicity of AA-AGE was neutralized by the addition of an anti-AA-AGE-specific antibody, but not by anti-N-ethyllysine (NEL) antibody. The AA-AGE epitope was detected in human brain of alcoholism. We propose that the structural epitope AA-AGE is an important toxic moiety for neuronal cells in alcoholism.

References

Jan 1, 1992·Advances in Pharmacology·R Bucala, A Cerami
Jan 1, 1995·Annual Review of Medicine·M Brownlee
Aug 2, 1994·Proceedings of the National Academy of Sciences of the United States of America·S D YanM A Smith
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·M P VitekA Cerami
Jun 7, 1994·Proceedings of the National Academy of Sciences of the United States of America·M A SmithG Perry
Oct 20, 1998·The American Journal of Pathology·N SasakiZ Makita
Nov 25, 1998·Biochemical Pharmacology·G M ThieleL W Klassen
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·Y Al-AbedR Bucala
Oct 3, 1999·Methods in Enzymology·Y al-AbedR Bucala
Oct 7, 2000·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·J RintalaO Niemelä
Jan 9, 2001·Archives of Biochemistry and Biophysics·K S JeongB J Song
Jan 19, 2002·Biochemical and Biophysical Research Communications·Sho-ichi YamagishiZenji Makita
Oct 25, 2002·Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders : Official Publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases·J Michael Woolley

❮ Previous
Next ❯

Citations

Mar 10, 2010·Laboratory Investigation; a Journal of Technical Methods and Pathology·Masayoshi TakeuchiSho-ichi Yamagishi
Aug 8, 2013·PloS One·Nobuhiko HayashiMikihiro Tsutsumi
Jan 16, 2010·Basic & Clinical Pharmacology & Toxicology·Chris PickeringAsa Fex-Svenningsen
Jun 13, 2015·Mediators of Inflammation·Jorge M BarciaFrancisco J Romero
Apr 1, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·H J ChoI Mook-Jung
Nov 26, 2009·Psychological Reports·W L IsaacC Ray
Dec 31, 2005·Alcoholism, Clinical and Experimental Research·Masayoshi Takeuchi, Toshikazu Saito
Nov 18, 2010·Immunological Investigations·Zohara SternbergFrederick Munschauer
Jun 21, 2017·Nutrients·Masayoshi TakeuchiMikihiro Tsutsumi
Feb 12, 2021·Experimental & Molecular Medicine·Wiramon RungratanawanichByoung-Joon Song
May 2, 2008·Progress in Neurobiology·Jian-Zhi Wang, Fei Liu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.