PMID: 8959030Oct 31, 1996Paper

Neurotoxicity of d-amphetamine in the C57BL/6J and CD-1 mouse. Interactions with stress and the adrenal system

Annals of the New York Academy of Sciences
D B Miller, J P O'Callaghan

Abstract

Substantial evidence suggests that stress can alter the general toxicological properties of the substituted amphetamines (AMPs) as well as their psychostimulant properties. Research concerning the interactions between stress and the neurotoxicity associated with the AMPs is, however, limited. Our previous work demonstrated that a variety of AMPs, including d-METH, d-MDA, d-MDMA but not d-FEN are able to damage dopaminergic elements of the striatum as shown by decreases in dopamine and tyrosine hydroxylase. The neurotoxic capabilities of these AMPs appear linked to their hyperpyrexic actions as diverse manipulations able to block AMP-induced hyperthermia are also neuroprotective. Surprising, since stress usually potentiates the actions of the AMPs, it is our finding that restraint, a commonly used stressor, is protective against the injurious actions of all neurotoxic AMPs evaluated to date. In the mouse restraint acts to elevate blood levels of corticosterone (CORT) by activating the hypothalamic-pituitary-adrenal (HPA) axis as well as inducing a profound hypothermia. The role CORT may play in the neuroprotective actions of restraint, if any, is unknown. Here, data is presented showing the impact of several HPA axis manipulatio...Continue Reading

References

Feb 1, 1977·British Journal of Haematology·G R MilnerL G Lajtha
Aug 15, 1977·European Journal of Pharmacology·M C Wilson
Sep 1, 1992·Pharmacology, Biochemistry, and Behavior·A BadianiS Puglisi-Allegra
Jan 1, 1992·Neuroscience and Biobehavioral Reviews·E O JohnsonP W Gold
Nov 1, 1991·The American Journal of the Medical Sciences·B R Ganong
Jan 1, 1992·Physiology & Behavior·A Cabanac, E Briese
Feb 28, 1989·European Journal of Pharmacology·M JohnsonJ W Gibb
Aug 2, 1988·European Journal of Pharmacology·J E Faunt, A D Crocker
Jan 1, 1988·Progress in Neuro-psychopharmacology & Biological Psychiatry·P K Sonsalla, R E Heikkila
Oct 1, 1985·Analytical Biochemistry·P K SmithD C Klenk
Jan 1, 1984·Endocrine Reviews·M E Keller-Wood, M F Dallman
Jan 1, 1984·Psychopharmacology·J P HermanM Le Moal
Oct 31, 1996·Annals of the New York Academy of Sciences·D B Miller, J P O'Callaghan
Oct 1, 1952·Physiological Reviews·T F DOUGHERTY
Nov 1, 1958·The Anatomical Record·K P HUMMEL

❮ Previous
Next ❯

Citations

Apr 24, 2007·Neurotoxicity Research·Jean Lud CadetJohnalyn Lyles
Apr 20, 2000·European Journal of Pharmacology·E E Elliot, J M White
Dec 2, 1998·Neuropharmacology·T KitaT Nakashima
Apr 23, 2003·Environmental Research·Diane B Miller, James P O'Callaghan
Sep 1, 2004·Neuroscience Letters·David M ThomasDonald M Kuhn
Oct 2, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jean Lud CadetXiaolin Deng
Oct 16, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lisa J MaddenHoward S Fox
Oct 31, 1996·Annals of the New York Academy of Sciences·D B Miller, J P O'Callaghan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.