Neurotoxicity of fungal volatile organic compounds in Drosophila melanogaster

Toxicological Sciences : an Official Journal of the Society of Toxicology
Arati A InamdarJoan Wennstrom Bennett

Abstract

Many volatile organic compounds (VOCs) are found in indoor environment as products of microbial metabolism. In damp indoor environments, fungi are associated with poor air quality. Some epidemiological studies have suggested that microbial VOCs have a negative impact on human health. Our study was designed to provide a reductionist approach toward studying fungal VOC-mediated toxicity using the inexpensive model organism, Drosophila melanogaster, and pure chemical standards of several important fungal VOCs. Low concentrations of the following known fungal VOCs, 0.1% of 1-octen-3-ol and 0.5% of 2-octanone; 2,5 dimethylfuran; 3-octanol; and trans-2-octenal, caused locomotory defects and changes in green fluorescent protein (GFP)- and antigen-labeled dopaminergic neurons in adult D. melanogaster. Locomotory defects could be partially rescued with L-DOPA. Ingestion of the antioxidant, vitamin E, improved the survival span and delayed the VOC-mediated changes in dopaminergic neurons, indicating that the VOC-mediated toxicity was due, in part, to generation of reactive oxygen species.

References

Jan 1, 1978·Methods in Enzymology·J A Buege, S D Aust
Jul 1, 1987·Chemistry and Physics of Lipids·E Niki
Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·D B Campbell, H A Nash
Apr 15, 1996·Toxicology·M KamijimaY Takeuchi
Aug 1, 1996·The Annals of Occupational Hygiene·A L SunessonG Blomquist
Mar 1, 1997·Journal of Applied Toxicology : JAT·R Wasserkort, T Koller
Apr 29, 1998·Journal of the European Academy of Dermatology and Venereology : JEADV·R WolfV Ruocco
Dec 23, 1998·Occupational and Environmental Medicine·J D CooleyD C Straus
May 15, 2001·Journal of Neurobiology·W NeckameyerW Stark
Jul 16, 2002·Environmental Health Perspectives·Sydney M GordonDonald V Kenny
Oct 29, 2002·Journal of Environmental Monitoring : JEM·Anna-Sara ClaesonAnna-Lena Sunesson
Jan 15, 2003·Clinical Microbiology Reviews·D M Kuhn, M A Ghannoum
Jan 24, 2004·Occupational and Environmental Medicine·P S Burge
Jul 21, 2004·Archives of Environmental Health·David C StrausCynthia A Jumper
Sep 8, 2004·Advances in Applied Microbiology·De-Wei Li, Chin S Yang
Nov 24, 2004·International Archives of Occupational and Environmental Health·Y SaijoT Umemura
Nov 27, 2004·Applied Microbiology and Biotechnology·Bruce B Jarvis, J David Miller
Dec 3, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hélène Coulom, Serge Birman
Mar 16, 2005·Behavioural Pharmacology·O Cauli, M Morelli
Aug 1, 1995·Applied and Environmental Microbiology·A SunessonR Carlson
Jun 20, 2006·Genetics·Katherine W JordanTrudy F C Mackay
Aug 30, 2006·Proceedings of the National Academy of Sciences of the United States of America·Danling WangZhuohua Zhang
Oct 13, 2006·Bulletin of Environmental Contamination and Toxicology·F KondoY Miyazaki
Feb 20, 2007·Molecular Aspects of Medicine·Roberta RicciarelliCinzia Domenicotti
Mar 9, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anathbandhu ChaudhuriJanis M O'Donnell
Jul 20, 2007·The New Phytologist·Richard SplivalloPaola Bonfante
Oct 16, 2007·International Journal of Hygiene and Environmental Health·Guido FischerPeter Kämpfer
Apr 4, 2008·Proceedings of the National Academy of Sciences of the United States of America·Divya SitaramanTroy Zars
Jun 26, 2008·Journal of Microbiological Methods·Silke MatysikAndrea Mueller
Jul 22, 2008·Methods in Molecular Biology·Alfonso Martinez Arias
Dec 10, 2008·Arhiv za higijenu rada i toksikologiju·Sibel BayilMuhsin Hazar
Feb 11, 2009·Critical Reviews in Toxicology·Anne KorpiAnna-Liisa Pasanen
Jun 9, 2009·Free Radical Biology & Medicine·Etsuo Niki
Oct 27, 2009·Toxicology and Industrial Health·L D Empting
Oct 27, 2009·Toxicology and Industrial Health·David C Straus

❮ Previous
Next ❯

Citations

Jan 8, 2014·Canadian Journal of Microbiology·Kirsten HokenessChristopher W Reid
Nov 13, 2013·Proceedings of the National Academy of Sciences of the United States of America·Arati A InamdarJoan Wennstrom Bennett
Sep 25, 2015·Toxins·Joan W Bennett, Arati A Inamdar
Nov 10, 2012·Environmental Toxicology·Arati A InamdarJoan W Bennett
Apr 9, 2015·Frontiers in Microbiology·Joan W Bennett
Mar 17, 2015·Applied Microbiology and Biotechnology·Richard HungJoan W Bennett
Sep 27, 2014·Biosensors & Bioelectronics·F Di PietrantonioS D'Auria
Feb 17, 2017·Natural Product Reports·Jeroen S Dickschat
Feb 21, 2018·Microbiology·Hazael Hernandez, Luis R Martinez
Jan 27, 2018·Mycobiology·Hadeel Saeed Al-MalikiJoan W Bennett
Aug 9, 2019·Pest Management Science·Salim KhojaTariq Butt
Apr 10, 2020·Frontiers in Neuroscience·Moamen M Elmassry, Birgit Piechulla
Sep 20, 2018·Environmental Science and Pollution Research International·Samuel Lima de SantanaClaudia Rohde
May 2, 2019·American Journal of Physiology. Renal Physiology·Victoria L Halperin KuhnsJennifer L Pluznick
Sep 6, 2020·Ecotoxicology and Environmental Safety·Giulianna Echeverria MacedoThaís Posser

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.