PMID: 9192217Jan 1, 1997Paper

Neurotoxicity of long-term low-level exposure to carbon disulphide: results of questionnaire, clinical neurological examination and neuropsychological testing

International Archives of Occupational and Environmental Health
F ReinhardtB Neundörfer

Abstract

Carbon disulphide (CS2) is highly neurotoxic. There is ample evidence of damage to the peripheral and central nervous system. The air concentration at which such adverse effects can first be observed is presently a subject of controversy. In a cross-sectional study of CS2-exposed workers from the viscose industry and healthy controls, data on neurological complaints, basic laboratory diagnosis, clinical neurological examination and neuropsychological testing were evaluated. Data were from 222 workers in the viscose industry exposed to CS2 and 191 employees from the same factory with similar physical and psychological stress factors but without occupational contact with neurotoxic substances. Multiple linear or multiple logistic regression analysis was used to check for statistical differences. The median of the CS2-measurements using personal air sampling was below the current maximum concentration permissible (MAK value) in Germany (10 ppm) in all departments. The threshold limit value was, however, exceeded in almost 10% of the persons investigated. Exposure fluctuated between < 0.2 and 65.7 ppm (median of all departments was 4.02 ppm). As a parameter of internal exposure, CS2-metabolite 2-thio-1,3-thiazolidine-4-carboxylic a...Continue Reading

Citations

Aug 27, 2003·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·Y BiY Su
May 14, 2003·Ecotoxicology and Environmental Safety·Xiaodong TanPhilippe Hartemann
Dec 4, 2003·Journal of Occupational Health·Srmena KrstevRadmila Banićević
Oct 10, 2002·Acta Neurologica Scandinavica·S K ChoM A Son
Mar 1, 2006·International Journal of Hygiene and Environmental Health·Lode GodderisMineke Viaene
Aug 31, 2002·Environmental Toxicology·Xiaodong TanPhilippe Hartemann

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