Neurotoxicity of MDMA (ecstasy): the limitations of scaling from animals to humans

Trends in Pharmacological Sciences
Rafael de la Torre, Magí Farré

Abstract

Several studies suggest that MDMA-induced acute toxicity and long-term neurotoxicity is dependent on the metabolic disposition of MDMA. Differences in MDMA metabolism among animal species might therefore account for different sensitivities to its neurotoxic effects. The kinetic parameters of enzymes that regulate the formation of neurotoxic metabolites of MDMA differ among species, as does the ability of MDMA to self-inhibit these enzymes and the degree of genetic polymorphisms exhibited by these enzymes. Such features limit allometric scaling across animal models.

References

Jun 1, 1997·Biochemical Pharmacology·D WuE M Sellers
Mar 21, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·U D McCann, G A Ricaurte
Apr 20, 2001·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J J BogaardsB Walther
Jul 19, 2003·Pharmacological Reviews·A Richard GreenM Isabel Colado
Jan 7, 2004·Drug Metabolism Reviews·Frank J Gonzalez
Mar 25, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·William E FantegrossiGail Winger
Jul 2, 2004·Therapeutic Drug Monitoring·Rafael de la TorreJordi Camí

❮ Previous
Next ❯

Citations

Nov 2, 2013·Archives of Toxicology·Daniel José BarbosaFélix Carvalho
Mar 5, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Joseph M HerndonTerrence J Monks
Aug 13, 2014·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·V Ferraz-de-PaulaJ Palermo-Neto
Sep 1, 2007·Behavioural Pharmacology·Charles V VorheesMichael T Williams
Feb 3, 2009·Analytical and Bioanalytical Chemistry·Melanie MuellerHans H Maurer
Apr 8, 2009·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Ximena PerfettiRafael de la Torre
Aug 15, 2009·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Michael H BaumannMarilyn A Huestis
Oct 22, 2013·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Marta ConcheiroMarilyn A Huestis
Dec 20, 2005·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Sameera Dasari, Robin L Cooper
Dec 17, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Déborah HirtJean-Michel Scherrmann
Aug 24, 2010·Journal of the International Neuropsychological Society : JINS·Mariana ChernerUNKNOWN HNRC Group
Apr 18, 2009·Molecular Neurobiology·João Paulo CapelaFélix Carvalho
Sep 21, 2010·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Donna Seger
Mar 15, 2012·Neuroscience Research·Anna KubesovaJiri Horacek
Jul 6, 2010·European Journal of Pharmacology·Jalal PourahmadAli Reza Khajeamiri
Jul 10, 2007·European Journal of Pharmacology·Jean-Christophe CasselByron C Jones
May 1, 2007·Neuroscience·J P CapelaF Carvalho
Nov 18, 2006·Neuroscience and Biobehavioral Reviews·Kelly Allott, Jennifer Redman
Dec 19, 2006·Neurotoxicology and Teratology·Brian J Piper
Dec 29, 2006·Chemistry & Biodiversity·Daniel TrachselFranz Baumberger
Dec 1, 2007·Basic & Clinical Pharmacology & Toxicology·Sunniva Nyberg KarlsenLars Slørdal
Nov 11, 2008·Annals of the New York Academy of Sciences·Jerrold S MeyerValerie E Vancollie
Dec 8, 2010·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Rafael Guimarães Dos Santos

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.