Neurotoxocarosis alters myelin protein gene transcription and expression

Parasitology Research
Lea HeuerChristina Strube

Abstract

Neurotoxocarosis is an infection of the central nervous system caused by migrating larvae of the common dog and cat roundworms (Toxocara canis and Toxocara cati), which are zoonotic agents. As these parasites are prevalent worldwide and neuropathological and molecular investigations on neurotoxocarosis are scare, this study aims to characterise nerve fibre demyelination associated with neurotoxocarosis on a molecular level. Transcription of eight myelin-associated genes (Cnp, Mag, Mbp, Mog, Mrf-1, Nogo-A, Plp1, Olig2) was determined in the mouse model during six time points of the chronic phase of infection using qRT-PCR. Expression of selected proteins was analysed by Western blotting or immunohistochemistry. Additionally, demyelination and neuronal damage were investigated histologically. Significant differences (p ≤ 0.05) between transcription rates of T. canis-infected and uninfected control mice were detected for all analysed genes while T. cati affected five of eight investigated genes. Interestingly, 2', 3 ´-cyclic nucleotide 3'-phosphodiesterase (Cnp) and myelin oligodendrocyte glycoprotein (Mog) were upregulated in both T. canis- and T. cati-infected mice preceding demyelination. Later, CNPase expression was additional...Continue Reading

References

May 1, 1991·The Pediatric Infectious Disease Journal·J D FortenberryJ Younger
Aug 12, 1989·Lancet·L Russegger, E Schmutzhard
Sep 1, 1989·The American Journal of Tropical Medicine and Hygiene·P M Schantz
Nov 2, 1985·British Medical Journal·I M GouldR H George
May 1, 1974·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·N Z MikhaelM T Richard
Feb 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry·C SommerW M Glöckner
Nov 26, 1998·Molecular and Cellular Neurosciences·P MorellG K Matsushima
Jul 30, 1999·Journal of Neuroimmunology·W F Blakemore, H S Keirstead
Mar 29, 2001·Physiological Reviews·N Baumann, D Pham-Dinh
Apr 12, 2003·Trends in Parasitology·Maggie Fisher
Nov 1, 1956·Experimental Parasitology·P C BEAVER
Oct 1, 1951·The Journal of Pathology and Bacteriology·W BEAUTYMAN, A L WOOLF
Apr 20, 2004·Revista Da Sociedade Brasileira De Medicina Tropical·Sandra F Moreira-SilvaFausto E L Pereira
Jun 15, 2004·Medical Hypotheses·Hans Peter Söndergaard, Töres Theorell
Sep 28, 2005·Journal of Anatomy·Chao ZhaoRobin J M Franklin
Jan 13, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·S Hossein FatemiMitsunori Fukuda
Aug 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Lyudmila GeorgievaMichael C O'Donovan
Mar 16, 2007·Journal of Neuropathology and Experimental Neurology·Tanja KuhlmannWolfgang Brück
Nov 21, 2007·Revista Do Instituto De Medicina Tropical De São Paulo·Josef Finsterer, Herbert Auer
Jul 9, 2008·Journal of Molecular Neuroscience : MN·Enrica BodaFilippo Tempia
Apr 1, 2009·PLoS Neglected Tropical Diseases·Peter J Hotez, Patricia P Wilkins
Mar 10, 2010·Neurobiology of Disease·Johanna KnöferlePaul Lingor
May 4, 2011·Parasitology Research·Petra KolbekováLibuše Kolářová
Mar 14, 2012·Nature Reviews. Genetics·Christine Vogel, Edward M Marcotte
Apr 5, 2012·EMBO Molecular Medicine·Nora HagemeyerHannelore Ehrenreich
Dec 12, 2012·Neuron·Kaj BlennowHenrik Zetterberg
Dec 24, 2014·Case Reports in Neurology·Christian Sick, Michael G Hennerici

❮ Previous
Next ❯

Citations

Oct 21, 2015·Journal of Parasitology Research·Cosme Alvarado-EsquivelLuis Francisco Sánchez-Anguiano
Jun 18, 2015·Parasitology·Lea HeuerChristina Strube
Dec 2, 2020·Revue neurologique·L LegrisO Casez

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.