Neurotransmitter activity is linked to outcome following subthalamic deep brain stimulation in Parkinson's disease

Parkinsonism & Related Disorders
Ruth L O'Gorman TuuraHeide Baumann-Vogel

Abstract

While the mechanisms underlying the therapeutic effects of deep brain stimulation (DBS) in Parkinson's Disease (PD) are not yet fully understood, DBS appears to exert a wide range of neurochemical effects on the network level, thought to arise from activation of inhibitory and excitatory pathways. The activity within the primary inhibitory (GABAergic) and excitatory (glutamatergic) neurotransmitter systems may therefore play an important role in the therapeutic efficacy of DBS in PD. The purpose of this study was to investigate abnormalities in GABA-ergic and glutamatergic neurotransmission in PD, and to examine the link between neurotransmitter levels and outcome following DBS. Magnetic resonance spectra were acquired from the pons and basal ganglia in sixteen patients with PD and sixteen matched control participants. GABA and glutamate levels were quantified with LCModel, an automated spectral fitting package. Fourteen patients subsequently underwent DBS, and PD symptoms were evaluated with the MDS-UPDRS at baseline and six months after surgery. The efficacy of DBS treatment was evaluated from the percentage improvement in MDS-UPDRS scores. Basal ganglia GABA levels were significantly higher in PD patients relative to control...Continue Reading

Citations

Apr 18, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Muhammad G SalehThomas Ernst
Oct 16, 2018·Frontiers in Neurology·Ruth L O'Gorman TuuraHeide Baumann-Vogel
Aug 8, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·David A EdmondsonUlrike Dydak
Feb 7, 2021·Journal of the Neurological Sciences·Yulu SongRichard A E Edden
Mar 22, 2021·Magma·Yulu SongRichard A E Edden

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