Neurotransmitter amino acid in cerebrospinal fluid of patients with dementia with Lewy bodies

Journal of Neural Transmission
J A MolinaJ Manzanares

Abstract

The purpose of the present study was to compare neurotransmitter amino acid concentrations in the cerebrospinal fluid (CSF) and CSF/plasma ratios in 21 patients with dementia with Lewy bodies (DLB) and 26 matched controls. To this purpose, we used an ion-exchange chromatographic method. DLB patients exhibit higher CSF concentrations of asparagine (+25%) and glycine (+21%) compared to a control group, whereas no differences in CSF/plasma ratios were found between both groups. On the other hand, no alterations in concentrations of glutamate, aspartate and GABA were detected in CSF of patients compared to a control group. There was no correlation among amino acid levels and CSF/plasma ratios with age, age of onset, body mass index, duration of the disease or scores of the Mini Mental State Examination, UPDRS and Hoehn and Yahr stage. These results suggest a possible role of glycine and asparagine in the pathogenic mechanism of dementia with Lewy bodies.

Citations

Nov 5, 2010·International Journal of Alzheimer's Disease·Elizabeta B Mukaetova-LadinskaElaine K Perry
May 30, 2013·Development·Daniel A BergAndrás Simon
Jun 16, 2007·NeuroImage·Vincenzo Di LazzaroPietro A Tonali
May 5, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Brit Mollenhauer, Claudia Trenkwalder
Dec 23, 2014·International Psychogeriatrics·Elizabeta B Mukaetova-Ladinska
Aug 29, 2009·Journal of Chemical Ecology·Esayas MendesilJohn A Pickett
Aug 20, 2019·American Journal of Alzheimer's Disease and Other Dementias·Ioannis MavroudisDimitrios Kazis

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