Neurotransmitter changes after traumatic brain injury: an update for new treatment strategies.

Molecular Psychiatry
Jennifer L McGuireRobert E McCullumsmith

Abstract

Traumatic brain injury (TBI) is a pervasive problem in the United States and worldwide, as the number of diagnosed individuals is increasing yearly and there are no efficacious therapeutic interventions. A large number of patients suffer with cognitive disabilities and psychiatric conditions after TBI, especially anxiety and depression. The constellation of post-injury cognitive and behavioral symptoms suggest permanent effects of injury on neurotransmission. Guided in part by preclinical studies, clinical trials have focused on high-yield pathophysiologic mechanisms, including protein aggregation, inflammation, metabolic disruption, cell generation, physiology, and alterations in neurotransmitter signaling. Despite successful treatment of experimental TBI in animal models, clinical studies based on these findings have failed to translate to humans. The current international effort to reshape TBI research is focusing on redefining the taxonomy and characterization of TBI. In addition, as the next round of clinical trials is pending, there is a pressing need to consider what the field has learned over the past two decades of research, and how we can best capitalize on this knowledge to inform the hypotheses for future innovation...Continue Reading

References

Jan 1, 1992·Journal of Neurotrauma·M R PrasadT K McIntosh
Aug 23, 1990·The New England Journal of Medicine·N R TemkinH R Winn
Jan 1, 1989·Progress in Neuro-psychopharmacology & Biological Psychiatry·R J Blanchard, D C Blanchard
Jan 1, 1995·Experimental Brain Research·T M ReevesJ T Povlishock
Mar 1, 1996·Pharmacology, Biochemistry, and Behavior·C E DixonR L Hayes
Feb 5, 1999·Progress in Brain Research·N C DanboltJ Storm-Mathisen
May 20, 1999·Pharmacopsychiatry·T J HuberH M Emrich
Nov 24, 1999·Biological Psychiatry·G Aston-JonesJ Cohen
May 8, 2000·Journal of Neuroscience Research·T M ReevesJ T Povlishock
Nov 1, 2000·Proceedings of the National Academy of Sciences of the United States of America·C IkonomidouL Turski
Jan 15, 2002·Nature Neuroscience·Jonathan LevensonArnold Eskin
Feb 5, 2003·Neurological Research·Toshiyuki FujinakaToshiki Yoshimine
Feb 26, 2003·Archives of Physical Medicine and Rehabilitation·John D CorriganGale Whiteneck
Jul 10, 2003·Lancet Neurology·Chrysanthy Ikonomidou, Lechoslaw Turski
Jul 10, 2003·Brain Injury : [BI]·Paul Bach-y-Rita
Jan 7, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Michael Gaetz
Mar 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Anat BiegonEsther Shohami
Dec 22, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Olli Tenovuo
May 26, 2005·The Annals of Pharmacotherapy·O'Rita M Siddall
Aug 27, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Patrick M KochanekEdwin K Jackson
Sep 30, 2005·Journal of Neurochemistry·A K WagnerC E Dixon
Oct 8, 2005·Science·Olivier PascualPhilip G Haydon
Dec 20, 2005·Current Opinion in Pharmacology·Keith W Muir
Jan 21, 2006·Nature Reviews. Drug Discovery·Stuart A Lipton

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Citations

Mar 14, 2020·International Journal of Molecular Sciences·Chu-Yuan ChangLinyi Chen
Feb 27, 2020·International Journal of Molecular Sciences·Chu-Yuan ChangLinyi Chen
Jan 29, 2019·Frontiers in Neuroscience·Laura B Ngwenya, Steve C Danzer
Oct 31, 2020·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Bin ZhouPing Yang
Mar 23, 2021·Frontiers in Behavioral Neuroscience·Taylor A McCorkleRamesh Raghupathi
Mar 31, 2021·Brain Research Bulletin·Niraja RanadiveJayesh Mudgal
Feb 3, 2021·Fundamental & Clinical Pharmacology·Dominique LerouetValérie C Besson
Jul 25, 2021·Proceedings of the National Academy of Sciences of the United States of America·Lennart R B SpindlerEmmanuel A Stamatakis
Sep 7, 2021·Brain Injury : [BI]·Kajal BagriRahul Deshmukh

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Clinical Trials Mentioned

NCT00462228

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