Neurotransmitter disturbances in some parts of the rat brain and their correction under chronic and intermittent alcohol intoxication

Biomedit︠s︡inskai︠a︡ khimii︠a︡
V K GushchaV M Sheibak

Abstract

The pool of key neuromediators and some neurotransmitter amino acids in cerebellum, hypothalamus and midbrain of rats exposed to chronic and different variants of interrupted alcohol intoxication was investigated. The most pronounced changes were recorded in midbrain. Chronic alcohol intoxication caused an increase in the concentrations of tyrosine, dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC), noradrenaline, tryptophan, serotonin, GABA and aspartate in this part of the rat brain. Interrupted alcohol intoxication with 4 days interval is accompanied by an increase in the content of tyrosine, and noradrenaline. Interrupted alcohol intoxication with 1 day interval leaded to an increase in the concentrations of tyrosine, DOPAC, noradrenalin, tryptophan, GABA, glycine and aspartate. The amino acids composition "Titacin" had a pronounced normalizing effect in the midbrain under interrupted alcohol intoxication with 1 day interval.

References

Jun 19, 1998·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·S BanoG L Gessa
Nov 30, 2007·Molecular Aspects of Medicine·Emanuele Albano
Jan 22, 2009·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Roberta J WardPhilippe de Witte

❮ Previous
Next ❯

Citations

Apr 2, 2020·International Journal of Molecular Sciences·Bin PengXin Wang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

© 2022 Meta ULC. All rights reserved