Neurotransmitter mechanisms of rat vagal afferent neurons

Clinical and Experimental Pharmacology & Physiology
A J Lawrence

Abstract

1. The present study has employed anatomical and neurochemical techniques to assess whether the amino acid, L-glutamate, may be considered as a potential neurotransmitter at rat vagal afferent neurons, with particular reference to baroreceptor afferents. 2. Slide-mounted sections of rat nodose ganglia were incubated with a high-titre antibody to glutamate, and visualization of the resulting immunoreactivity indicated glutamate-positive staining in a population of vagal afferent perikarya. In contrast, interstitial cells were devoid of immunostaining. 3. Release of endogenous glutamate was measured by in vivo microdialysis in the nucleus tractus solitarius, the site of central vagal afferent terminals, and could be evoked with a depolarizing stimulus of KCl in a calcium-dependent fashion. In addition, baroreceptor loading with an intravenous infusion of phenylephrine (30 micrograms/kg per min) increased the spontaneous efflux of glutamate to 148 +/- 28% of basal levels, which was paralleled by an increase in mean arterial pressure (approximately 40 mmHg). Release of glutamate was also elevated two-fold by intracerebral administration of S-nitroso-N-acetylpenicillamine (30 mumol/L), an effect that could be prevented by coadminist...Continue Reading

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Citations

Sep 3, 2008·Histochemistry and Cell Biology·Inge BrounsDirk Adriaensen
Jan 1, 1996·Progress in Neurobiology·A J Lawrence, B Jarrott
Dec 17, 1998·Physiology & Behavior·G A Burns, R C Ritter
Jun 1, 1997·Progress in Neurobiology·H ZhuoC J Helke
Nov 27, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ying LiChung Owyang
Dec 16, 2006·American Journal of Respiratory Cell and Molecular Biology·Isabel PintelonDirk Adriaensen
Jul 25, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gerlinda E HermannRichard C Rogers
Mar 22, 2014·Physiology & Behavior·Guillaume de Lartigue
Aug 10, 1999·Archives of Physiology and Biochemistry·I StoyanovaC Chouchkov
Sep 26, 2009·Journal of Chemical Neuroanatomy·Li-Hsien Lin
Mar 16, 2000·The American Journal of Medicine·D L Broussard, S M Altschuler
May 26, 2004·Physiology & Behavior·Robert C Ritter
Mar 17, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Deoclecio A ChiancaWilliam T Talman
Apr 22, 2006·The Journal of Comparative Neurology·Krzysztof CzajaGilbert A Burns
Oct 7, 1997·Clinical and Experimental Pharmacology & Physiology·A J Lawrence
Sep 27, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·T MutohJ P Joad
Apr 30, 2017·Medicina·Gintautas Grabauskas, Chung Owyang
Sep 7, 2021·Physiological Reviews·Alan G WattsWolfgang Langhans

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