PMID: 6111378Feb 16, 1981Paper

Neurotransmitter, receptor and biochemical changes in monkey cortical epileptic foci

Brain Research
R A Bakay, A B Harris

Abstract

Epileptic and normal Macaca mulatta monkey cortex was investigated using ligand binding techniques. Subpial injections of aluminum hydroxide gel into the left sensorimotor cortex produced stable seizure frequencies over a two year period and resulted in specific biochemical and receptor abnormalities. Pair matched CSF samples comparing epileptic and non-epileptic hemispheres showed a significant decreased GABA concentration over the epileptic side. The epileptic cortex demonstrated markedly reduced GABA receptor binding and diminished tissue GABA concentration and GAD activity. Two patterns of receptor loss were observed: nonspecific local cellular drop out involving multiple neurotransmitter receptors; and distal receptor loss which was specific for the neurotransmitter intervention pattern of the cortex. GABAergic receptor loss was more marked than receptor losses for the other neurotransmitter and was more widespread. Scatchard plot analysis demonstrated that the diminished GABAergic receptors within the focus were due to receptor loss and not affinity changes. Spearman rank correlations showed a significant correlation only between the degree of GABAergic receptor loss or decrease in GAD activity and the seizure frequency. ...Continue Reading

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Citations

Jun 3, 2005·Der Nervenarzt·H StefanM Buchfelder
May 16, 1983·Brain Research·T J Brennan, J R Haywood
Nov 1, 1987·Epilepsy Research·E W LothmanJ B Perlin
Jan 26, 1985·Lancet
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Apr 1, 1983·Neurochemical Research·J E Walker
May 12, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Erika Tovar-GudiñoMario Fernández-Zertuche

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