Neurotransmitter receptor genotypes associated with mental and behavioral disorders

Personalized Medicine
Ekrem VarogluBahar Taneri

Abstract

Investigation of association studies within the field of mental and behavioral disorders is of value given their complex molecular etiology including epistatic interactions of multiple genes with small effects. Utilizing biomedical text mining, associations are uncovered for all mental and behavioral conditions listed in Diagnostic and Statistical Manual of Mental Disorders Text Revision. Specifically, a computational pipeline is designed to retrieve neurotransmitter receptor variations from biomedical literature with a text mining approach, where unique polymorphisms are also mined. Analyses of 1337 unique neurotransmitter receptors and 465 distinct conditions yield 1568 unique gene-disease associations. This study takes an unconventional approach to association studies and generates a novel dataset of associations for disorders such as major depression and schizophrenia, which provides a global perspective for their genetic etiology.

References

Apr 23, 2003·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Erik G JönssonGöran C Sedvall
Dec 4, 2003·European Psychiatry : the Journal of the Association of European Psychiatrists·G PonceT Palomo
Feb 19, 2004·European Psychiatry : the Journal of the Association of European Psychiatrists·P Gorwood
Sep 29, 2005·The Journal of Clinical Psychiatry·Eric Q WuJyoti Aggarwal
Oct 18, 2008·Genome Biology·Martin KrallingerAlfonso Valencia
Jan 31, 2009·Behavioural Pharmacology·Bernard Le FollPhilip Gorwood
Apr 7, 2009·Pharmacology, Biochemistry, and Behavior·Christianne Esposito-SmythersValerie S Knopik
Apr 21, 2010·Cell·Jon McClellan, Mary-Claire King
Dec 15, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Robert A MoyerWolfgang Sadee
Aug 25, 2012·Current Topics in Behavioral Neurosciences·Karen Hodgson, Peter McGuffin
Jan 18, 2013·BMC Bioinformatics·Raheel NawazSophia Ananiadou
Feb 2, 2013·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Philippe LaraméeJean-Bernard Daeppen
Apr 25, 2013·Journal of Affective Disorders·M EkmanM Landén
Jun 12, 2013·Social Psychiatry and Psychiatric Epidemiology·Mattias EkmanMikael Landén
Jun 19, 2013·Behavioural Brain Research·Antonio M Persico, Valerio Napolioni
Oct 22, 2013·Gene·Shweta SinghYamini Jaiswal
Dec 24, 2013·Annals of Human Genetics·Toni-Kim ClarkeWade H Berrettini
Jan 15, 2014·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Lara A RayRaymond F Anton
May 27, 2014·Journal of Biomedical Informatics·Isabel Segura-BedmarMaría Herrero-Zazo
Jan 29, 2016·Perspectives on Psychological Science : a Journal of the Association for Psychological Science·Robert PlominJenae M Neiderhiser
Apr 14, 2016·PloS One·A S M Ashique MahmoodK Vijay-Shanker
Apr 29, 2016·Journal of the American Medical Informatics Association : JAMIA·Ayush SinghalZhiyong Lu
Nov 1, 2016·Nature Medicine·Michael C O'Donovan, Michael J Owen

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Methods Mentioned

BETA
pharmacotherapy
Feature extraction

Software Mentioned

SVM light
Genia Tagger

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