PMID: 6103733May 19, 1980Paper

Neurotransmitter receptor localizations: brain lesion induced alterations in benzodiazepine, GABA, beta-adrenergic and histamine H1-receptor binding

Brain Research
R S ChangS H Snyder

Abstract

Selective neuronal lesions have been utilized in efforts to localize binding sites in rat brain for beta-adrenergic, gamma-aminobutyric acid (GABA), histamine H1 and benzodiazepine receptors. The various receptors respond differentially to lesions both in extent of change and in time course. After kainate lesions in the corpus striatum, benzodiazepine receptors are depleted up to 45% at 45--78 days but are unaffected after 7 days. By contrast striatal GABA receptors are increased at 7 days but depleted at later times. Thus both striatal benzodiazepine and GABA receptors appear to be associated at least in part with intrinsic neurons. In the cerebellum both benzodiazepine and GABA receptors are reduced in kainate treated rats and in Nervous mice, mutants which lack Purkinje cells. The most pronounced dissimilarity between benzodiazepine and GABA receptors occurs in Weaver mice, which selectively lack granule cells and display a 60% reduction in GABA receptors but a 40% augmentation in benzodiazepine receptors. A major portion of cerebellar GABA receptors, therefore, appear to be localized to granule cells. Striatal beta-adrenergic receptors are reduced following intrastriatal kainate injections but are unaffected by cerebral cor...Continue Reading

References

Mar 15, 1978·European Journal of Pharmacology·R S Chang, S H Snyder
Jul 27, 1978·Nature·J F TallmanD W Gallager
Sep 8, 1978·Brain Research·R ZaczekJ T Coyle
Oct 7, 1977·Science·R M Herndon, J T Coyle
Jan 27, 1978·Brain Research·J W Olney, T de Gubareff
Jul 21, 1978·Brain Research·M GarbargJ C Schwartz
Sep 1, 1978·The British Journal of Psychiatry : the Journal of Mental Science·H Möhler, T Okada
Oct 1, 1978·European Journal of Pharmacology·S R Nahorski
Dec 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·V T TranS H Snyder
Aug 1, 1978·European Journal of Pharmacology·R SchwarczJ T Coyle
Sep 1, 1978·The British Journal of Psychiatry : the Journal of Mental Science·C Braestrup, R F Squires
Nov 1, 1978·Neuropharmacology·F A Henn, D J Henke
Jun 10, 1977·Brain Research·P L McGeerK Singh
Feb 1, 1976·Journal of Neurochemistry·G BarbinJ Storm-Mathisen
Feb 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·K SaitoJ E Vaughn
Aug 1, 1978·Neuroscience Letters·C BraestrupA Schousboe

❮ Previous
Next ❯

Citations

Aug 11, 1981·Molecular and Cellular Biochemistry·P Krogsgaard-Larsen, E Falch
Nov 1, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·H K LeeB J Hoffer
Apr 1, 1982·Agents and Actions·Z Huszti
Jun 20, 1983·Brain Research·S J KishO Hornykiewicz
May 7, 1984·Brain Research·M GoedertP C Emson
Jan 1, 1983·Neuroscience and Biobehavioral Reviews·E A Stone
Oct 1, 1989·Brain Research. Brain Research Reviews·E A Stone, M A Ariano
Dec 15, 1987·Brain Research·A Frostholm, A Rotter
Jan 1, 1982·Neurochemistry International·J Palacios, M J Kuhar
Jan 1, 1984·Progress in Neuro-psychopharmacology & Biological Psychiatry·P L WoodN P Nair
Jan 1, 1994·Progress in Neurobiology·G Sperk
Nov 1, 1980·Neuroscience Letters·M Willow, I G Morgan
Jan 1, 1983·General Pharmacology·F V DeFeudis
Aug 1, 1983·Neuroscience·F Roberts, C R Calcutt
Feb 1, 1986·Brain Research Bulletin·A Frostholm, A Rotter
Oct 6, 1997·Neurochemistry International·V Chaparro-HuertaA Feria-Velasco

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.