PMID: 38619Jul 1, 1979

Neurotransmitter regulation of arginine vasotocin release from rat pineal glands in vitro

Acta Endocrinologica
J L SartinR J Orts


Studies were performed to determine the effects of neurotransmitters on arginine vasotocin (AVT) release in vitro. Rat pineal glands were incubated with 10(-8)M or 10(-6)M norepinephrine (NE), dopamine (DA), serotonin (5HT), and acetylcholine (ACH) for eight h after which the concentrations of AVT in the media were determined by radioimmunoassay. With the exception of ACH, none of the neurotransmitters had a significant effect on AVT release. ACH significantly (P less than 0.05) elevated AVT release in vitro at the 10(-6)M concentration but not at the 10(-8)M concentration. The data indicate that ACH may play a role in the regulation of rat pineal gland secretion of AVT in vitro.


Aug 8, 2006·The Journal of Veterinary Medical Science·Masaru UsuiKoichi Mamba
Jan 1, 1990·Journal of Pineal Research·P Phansuwan-PujitoM Ebadi

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Acetylcholine Sulfate (1: 1)
Argipressin Tannate
Norepinephrine, (+, -)-Isomer
Pineal Gland

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