Neurotransmitter regulation of MAP kinase signaling in striatal neurons in primary culture

Synapse
S R VincentJ Bockaert

Abstract

Glutamate and dopamine are important neurotransmitters in the basal ganglia. Dopamine can act via D1 receptors to activate adenylyl cyclase in striatal neurons, while glutamate stimulation of NMDA receptors leads to an increase in intracellular calcium. Increases in intracellular calcium or cAMP can induce immediate early gene expression in striatal neurons. In the present study, NMDA receptor stimulation or adenylyl cyclase activation resulted in the activation of MAP kinase in striatal neurons in primary culture. The effect of cAMP appeared to involve cAMP-dependent protein kinase, in addition to a tyrosine kinase and MEK. NMDA-induced MAP kinase activation was also dependent on a tyrosine kinase and MEK. The EGF receptor, which has been implicated in calcium- and G protein-induced MAP kinase activation, did not mediate the effects of NMDA or forskolin on MAP kinase. Furthermore, the src kinase inhibitor, herbimycin A, and the phosphoinositol-3-kinase inhibitor, wortmannin, did not prevent MAP kinase activation by these stimuli. However, the ability of both NMDA and forskolin to activate MAP kinase in striatal neurons was blocked by SB 203580, an inhibitor of p38 reactivating kinase. These results indicate that both NMDA rece...Continue Reading

References

Sep 1, 1992·Neuron·J Schlessinger, A Ullrich
Feb 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S T YoungM J Iadarola
May 1, 1987·Molecular and Cellular Biology·C A CartwrightW Eckhart
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·S WeissJ Bockaert
Nov 17, 1995·The Journal of Biological Chemistry·R M KramerE M Johnstone
Nov 1, 1994·European Journal of Biochemistry·N Osherov, A Levitzki
Nov 1, 1994·Neuropharmacology·J RodriguezJ Bockaert
Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·K TouharaR J Lefkowitz
Jul 21, 1995·The Journal of Biological Chemistry·B E HawesR J Lefkowitz
Aug 15, 1995·Proceedings of the National Academy of Sciences of the United States of America·D T DudleyA R Saltiel
Feb 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·E J van CorvenW H Moolenaar
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·L M GravesE G Krebs
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·B R SevetsonJ C Lawrence
Nov 12, 1993·Science·S J Cook, F McCormick
Dec 30, 1994·Neuroreport·K B SeroogyH I Kornblum
Feb 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·L B Rosen, M E Greenberg

❮ Previous
Next ❯

Citations

Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·Z YanP Greengard
Feb 16, 2005·Developmental Neuroscience·Kelvin C Luk, Abbas F Sadikot
Jun 9, 2004·Neurotoxicity Research·Richard J Beninger, Todor Gerdjikov
Apr 26, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Aiqun LiJiawei Zhou
Apr 2, 2004·The Journal of Pharmacology and Experimental Therapeutics·Daniella L Muller, Ellen M Unterwald
Oct 17, 2003·Neuroreport·Mariana AlonsoMartín Cammarota
Jun 2, 2001·Journal of Neurophysiology·A L Purcell, T J Carew
Jan 1, 2013·Indian Journal of Sleep Medicine·Matthew W O'Malley, Subimal Datta

❮ Previous
Next ❯

Related Concepts

Related Feeds

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.