PMID: 8989400Oct 1, 1995Paper

Neurotransmitter regulation of the heart in the nudibranch Archidoris montereyensis

Journal of Neurophysiology
B L Wiens, P H Brownell

Abstract

1. The heart of the nudibranch mollusc Archidoris montereyensis is uniquely responsive to regulation by identifiable cardiac motor neurons. The neurotransmitters mediating the strong excitatory and inhibitory actions of the neurons are unknown. 2. In this study we developed an infused, in vitro preparation of the Archidoris heart to determine which of several cardioactive transmitters described in mollusks could affect changes in the rate, amplitude, or tonus of cardiac contractions. Several neurotransmitters we tested increased the rate and amplitude of heart contractions, including serotonin (threshold < 10 nM), dopamine (100 nM), and the neuropeptides R15 alpha 2 (3 nM), small cardioactive peptide B (10 nM), and FMRFamide (20 microM). Myomodulin also excited the heart (0.8 microM) and potentiated the cardioexcitatory action of serotonin at subthreshold concentrations. 3. Only acetylcholine (10 nM) inhibited the heart, decreasing the rate, amplitude, and tonus of contraction. Glycine and the peptides substance P and R15 alpha 1 had no effect on the heart. 4. Antisera against the active neurotransmitters labeled central neurons and nerves innervating the heart in a pattern consistent with their putative cardioregulatory functi...Continue Reading

Citations

Feb 27, 2001·The Journal of Comparative Neurology·T Siegmund, G Korge
Dec 21, 2006·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·James M Newcomb, Paul S Katz
Sep 26, 2006·The Journal of Comparative Neurology·James M NewcombPaul S Katz
Apr 2, 2021·Integrative Organismal Biology·W H WatsonJ M Newcomb
Feb 20, 2010·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Kevin M CrispXong Yang

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