PMID: 37989Aug 3, 1979

Neurotransmitter-related enzymes in senile dementia of the Alzheimer type

Brain Research
P Davies

Abstract

Choline acetyltransferase (ChAT), acetylcholinesterase (AChE) and glutamic acid decarboxylase (GAD) activities were measured in 20 brain regions from autopsied control and senile dementia of the Alzheimer type (SDAT) cases. Large, widespread reductions in the activities of ChAT and AChE were found in tissues from SDAT cases, while GAD activities were reduced in 3 of the 20 regions investigated. AChE activity in cerebrospinal fluid from SDAT cases was similar to that found in samples from non-demented patients.

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Sep 1, 1976·Brain : a Journal of Neurology·D M BowenA N Davison
Dec 1, 1975·Journal of Neurochemistry·T L YakshH I Yamamura
Jan 1, 1976·Journal of the American Geriatrics Society·W Op den Velde, F C Stam
Sep 1, 1970·Journal of the Neurological Sciences·B E TomlinsonM Roth

Related Concepts

Senile Paranoid Dementia
Familial Alzheimer Disease (FAD)
Brain
ACHE
Glutamate Decarboxylase
Alzheimer's Disease
Neurohormones
Functional Cerebral Localization
Choline O-Acetyltransferase
Alzheimer Disease Type 1

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