PMID: 6107854Sep 11, 1980Paper

Neurotransmitter turnover in rat striatum is correlated with morphine self-administration

Nature
J E SmithJ D Lane

Abstract

Drugs of abuse probably exert their reinforcing effects through 'reward' pathways in the central nervous system (CNS). Neuronal systems mediating opiate reinforcement have been investigated using pharmacological and electrolytic lesion procedures. Drugs that interfere with catecholaminergic and cholinergic neuronal activity decrease intravenous (i.v.) morphine self-administration in monkeys and rats. Electrolytic lesion procedures in rats have demonstrated that the medial forebrain bundle and caudate nucleus are important in maintaining i.v. morphine self-administration. We have now carried out a direct investigation of striatal (caudate nucleus, putamen and globus pallidus) neuronal systems. We show here that striatal catecholaminergic systems are important in mediating opiate reinforcement, and present direct evidence for the involvement of neurotransmitter systems in morphine reward.

Citations

Nov 2, 1981·Life Sciences·M A Bozarth, R A Wise
Apr 1, 1982·Pharmacology, Biochemistry, and Behavior·C CoJ D Lane
Mar 1, 1984·Pharmacology, Biochemistry, and Behavior·J E SmithJ D Lane
Nov 1, 1988·Pharmacology, Biochemistry, and Behavior·T MiyauchiJ E Smith
Apr 1, 1989·Pharmacology, Biochemistry, and Behavior·S Izenwasser, C Kornetsky
Jun 1, 1996·Pharmacology, Biochemistry, and Behavior·L Williams-HembyL J Porrino
Nov 11, 2003·Trends in Pharmacological Sciences·Edwin H JacobsAnton N M Schoffelmeer
Jun 14, 2002·Drug and Alcohol Dependence·Ryan K LanierDonald T Lysle
Oct 8, 2008·Experimental and Clinical Psychopharmacology·Thomas J Martin, Eric Ewan
May 27, 2009·Brain, Behavior, and Immunity·R J WeberT J Martin
Sep 25, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Marco Leyton
May 1, 1983·Journal of Neurochemistry·M E FreemanJ E Smith
Jan 1, 1987·Neuroscience and Biobehavioral Reviews·T Hunt, Z Amit
Jan 1, 1989·Neuroscience and Biobehavioral Reviews·G F KoobF E Bloom
Jun 18, 2015·ACS Chemical Neuroscience·Seth H WaltersAdrian C Michael
Oct 28, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mark K Greenwald, Timothy A Roehrs
Jan 1, 2011·Pharmaceuticals·Alejandro Higuera-MatasEmilio Ambrosio
Mar 1, 1982·Pharmacology, Biochemistry, and Behavior·J E SmithJ D Lane

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